Amy Guimaraes Young

Mentor: Adam Dupuy, PhD

Year Entered Into Program: 2011

PhD Institution: University of Iowa, 2017

Affiliations

  • Anatomy and Cell Biology | Medical Scientist Training Program

Research Description

I am researching the genetics of gynecological cancers. Currently I am exploring the role of Sox17 in contributing to the increased glandular phenotype observed in endometrial cancer. Research in our lab to date suggests this transcription factor is also involved in normal glandular development in the uterus. I am also conducting a forward genetic screen. Population data indicate that obesity, menopause, and hormone replacement therapy are risk factors for the development of endometrial cancer. i am exposing a cohort of mice to these factors and collecting mutational data using insertional mutagenesis.

Awards

  • Fellowship appointment on the Pharmacological Sciences Training Program (NIH T32 GM067795), University of Iowa, 2013-2014
  • Institutional support on the Pharmacological Sciences Training Program (NIH T32 GM067795), University of Iowa, 2012-2013
  • Fellowship appointment on the Medical Scientist Training Program (NIH T32 GM007337), University of Iowa, 2009-2011

Publications

  1. Guimarães-Young, A, Neff, T, Dupuy, AJ., Goodheart, MJ.: Conditional deletion of Sox17 reveals complex effects on uterine adenogenesis and function. Developmental Biology, 414(2):219-227, 2016. PMCID: PMC5521196

Research