Jayden Bowen, M6G
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MSTP Learning Community: McCowen MSTP Entry Date: August 1, 2017 |
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PhD Program: Immunology |
Mentor: Julia Klesney-Tait, MD, PhD |
| Graduate Profile | Lab Website |
The role of TREM-1 in neutrophil biology and lung immunology
The Klesney-Tait lab investigates the intersection of lung immunology, neutrophil biology, and triggering receptor expressed on myeloid cells 1 (TREM-1.) The lungs represent a unique challenge for the immune system given their immense surface area, continuous exposure to the environment, and intricate architecture. Neutrophils are the most abundant leukocyte in the body and are often considered as "first responders" to infection and inflammation. TREM-1 is a surface receptor that acts to amplify innate inflammatory signaling through other receptors such as Toll-like receptors. The role of TREM-1 is context-dependent. TREM-1 plays an important role in appropriate immune responses, but in highly inflammatory states such as sepsis TREM-1 exacerbates disease. Utilizing mouse models of airway hyper-reactivity, we are currently investigating the roles of neutrophils and TREM-1 in asthma. Previous work in the lab has demonstrated that TREM-1 deficient neutrophils have an impaired ability to migrate across lung epithelium and generate superoxide. Preliminary evidence suggests that TREM-1 deficient mice are resistant to developing airway hyperreactivity. Our investigations aim to better understand which effects of TREM-1 deficiency contribute to protection from airway hyperreactivity.
Committees:
2017-2018 - CAPS 1 Liaison Committee
2018-2019 - MSTP Seminar Committee
2018-2019 - MSTP Applicant Task Force
2019-2022 - MSTP Admissions Committee Member
Awards:
2019 - Excellence in Internal Medicine Research Award - Medical Student Research Day, Sept 20
2020 - M2/PA2 Tutor of the Year
2020 - Excellence in Internal Medicine Research Award - Medical Student Research Day
2021 - University of Iowa Graduate College Post-Comprehensive Research Fellowship
2022 - Multidisciplinary Lung Research Center Career Development Program T32 Predoctoral Fellowship
Teaching:
2018 - Group Tutor, Foundations of Cellular Life
2018 - Group Tutor, Medical Gross Anatomy
2019 - Group Tutor, Mechanisms of Health and Disease II
2019-2020 - Lead Tutor, Mechanisms of Health and Disease IV
2019-2022 - Lead Tutor, Medical Gross Anatomy
2020-2021- Group Tutor, Medical Gross Anatomy Group Tutor
2021 - Teaching Assistant, Graduate Immunology
2022 - Instructor, Immunology and Human Disease Instructor
Education:
2016 - BS, Biology - Pittsburg State University
Publications:
Borbón TY, Scorza BM, Clay GM, Lima Nobre de Queiroz F, Sariol AJ, Bowen JL, Chen Y, Zhanbolat B, Parlet CP, Valadares DG, Cassel SL, Nauseef WM, Horswill AR, Sutterwala FS, Wilson ME. Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A. PLoS Negl Trop Dis. 2019 May;13(5):e0007247. doi: 10.1371/journal.pntd.0007247. eCollection 2019 May. PubMed PMID: 31107882; PubMed Central PMCID: PMC6527190.
Murthy S, Baruah S, Bowen JL, Keck K, Wagner BA, Buettner GR, Sykes DB, Klesney-Tait J. TREM-1 is required for enhanced OpZ-induced superoxide generation following priming. J Leukoc Biol. 2022 Jan 24. doi: 10.1002/JLB.3A0421-212R. Epub ahead of print. PMID: 35075692.