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Jayden Bowen, M5G

jayden-bowen@uiowa.edu

 

MSTP Learning Community: McCowen

MSTP Entry Date: August 1, 2017

PhD Program:

Immunology

Mentor:

Julia Klesney-Tait, MD, PhD

Graduate Profile Lab Website

The role of TREM-1 in neutrophil biology and lung immunology

The Klesney-Tait lab investigates the intersection of lung immunology, neutrophil biology, and triggering receptor expressed on myeloid cells 1 (TREM-1.) The lungs represent a unique challenge for the immune system given their immense surface area, continuous exposure to the environment, and intricate architecture. Neutrophils are the most abundant leukocyte in the body and are often considered as "first responders" to infection and inflammation. TREM-1 is a surface receptor that acts to amplify innate inflammatory signaling through other receptors such as Toll-like receptors. The role of TREM-1 is context-dependent. TREM-1 plays an important role in appropriate immune responses, but in highly inflammatory states such as sepsis TREM-1 exacerbates disease. Utilizing mouse models of airway hyper-reactivity, we are currently investigating the roles of neutrophils and TREM-1 in asthma. Previous work in the lab has demonstrated that TREM-1 deficient neutrophils have an impaired ability to migrate across lung epithelium and generate superoxide. Preliminary evidence suggests that TREM-1 deficient mice are resistant to developing airway hyperreactivity. Our investigations aim to better understand which effects of TREM-1 deficiency contribute to protection from airway hyperreactivity.


Committees:

  • 2017-2018 - CAPS 1 Liaison Committee
  • 2018-2019 - MSTP Seminar Committee
  • 2018-2019 - MSTP Applicant Task Force
  • 2019-2021 - MSTP Admissions Committee Member

Awards:

  • 2019 - Excellence in Internal Medicine Research Award - Medical Student Research Day, Sept 20
  • 2020 - M2/PA2 Tutor of the Year

Teaching:

  • 2018 Fall - M1 Foundations Tutor
  • 2018 Fall - M1 Anatomy Tutor
  • 2019 Spring - MOHD II Tutor
  • 2019-2020 MOHD IV Lead Tutor
  • 2019-Present - Medical Gross Anatomy Lead Tutor
  • 2020 Fall - Medical Gross Anatomy Group Tutor
  • 2020 Fall- MSCC Anatomy tutor

Education:

2016 - BS, Biology - Pittsburg State U

Publications:

ORCiD: 0000-0003-0110-6440

Borbón TY, Scorza BM, Clay GM, Lima Nobre de Queiroz F, Sariol AJ, Bowen JL, Chen Y, Zhanbolat B, Parlet CP, Valadares DG, Cassel SL, Nauseef WM, Horswill AR, Sutterwala FS, Wilson ME. Coinfection with Leishmania major and Staphylococcus aureus enhances the pathologic responses to both microbes through a pathway involving IL-17A. PLoS Negl Trop Dis. 2019 May;13(5):e0007247. doi: 10.1371/journal.pntd.0007247. eCollection 2019 May. PubMed PMID: 31107882; PubMed Central PMCID: PMC6527190.

Murthy S, Baruah S, Bowen JL, Keck K, Wagner BA, Buettner GR, Sykes DB, Klesney-Tait J. TREM-1 is required for enhanced OpZ-induced superoxide generation following priming. J Leukoc Biol. 2022 Jan 24. doi: 10.1002/JLB.3A0421-212R. Epub ahead of print. PMID: 35075692.