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Maddie Mix, M5G

 

madison-mix@uiowa.edu

 

MSTP Learning Community:  Flocks

MSTP Entry Date:  June 11, 2018

PhD Program:

Immunology

Mentor:

John Harty, PhD

Graduate Profile
Lab Profile
Lab Website

Neuroimmune interactions of tissue resident memory T cells

The central nervous system (CNS) was once considered to be an immune-privileged organ, but emerging evidence supports that the brain and spinal cord are populated by a variety of resident immune cells at homeostasis. Tissue resident memory (Trm) CD8 T cells are adaptive immune cells that do not recirculate but instead remain permanently situated in tissues like the CNS for rapid protection upon repeated neurological insult. Until recently, it was unknown whether prior CNS infection was absolutely required to generate Trm cell populations. Novel work in our lab has demonstrated that peripheral immunization strategies against viral and bacterial agents also induce antigen-specific Trm cell accumulation in the CNS but not other organs. Unlike most organs, the CNS possesses strict barrier structures, non-redundant anatomy, and broadly projecting neuromodulatory neurons. Given the endemic enrichment of peripherally-induced Trm cells in the CNS, my project seeks to address the role of these brain and spinal-cord specific features on Trm cell recruitment, distribution, maintenance, and function in the CNS.


Committees:

  • 2019 - Student Interest Group in Neurology (SIGN) Co-President (Jan-Dec)
  • 2019 - American Medical Women's Association (AMWA) Grand Rounds Chair (Jan-Dec)
  • 2018-2019 - Medical Student Ambassador Program (MSAP)
  • 2018-present - MSTP Retreat & I Heart Science Committee (Co-Chair 2021-2022)

Awards:

  • 2018 - William Johnson Award for Research in Microbiology & Immunology, Medical Student Research Conference, Sept 14
  • 2018 - Trainee Abstract Award, AAI Annual Meeting
  • 2019 - Francois M. Abboud Prize for Best Platform Presentation (U of I Foundation Award), Medical Student Research Conference, Sept 20

Teaching:

2021 Fall - MSTP Step 1 tutor

Education:

2017 - BA, Neuroscience - Wartburg College

Publications:

ORCiD:  0000-0002-2173-608X

Agostinelli LJ, Mix MR, Hefti MM, Scammell TE, Bassuk AG. Input-output connections of LJA5 prodynorphin neurons. J Comp Neurol. 2021 Feb;529(3):635-654. doi: 10.1002/cne.24974. Epub 2020 Jul 24. PubMed PMID: 32602558; PubMed Central PMCID: PMC7769903.

Lefebvre MN, Surette FA, Anthony SM, Vijay R, Jensen IJ, Pewe LL, Hancox LS, Van Braeckel-Budimir N, van de Wall S, Urban SL, Mix MR, Kurup SP, Badovinac VP, Butler NS, Harty JT.  Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell Rep. 2021 Nov 2;37(5):109956. doi: 10.1016/j.celrep.2021.109956. PubMed PMID: 34731605; PubMed Central PMCID: PMC8628427.