Chunyan Hu, PhD

Address: 2-340 BSB
Phone: (319) 335-8926
Email: chunyan-hu@uiowa.edu

Mentor: Curt D. Sigmund, PhD

PhD Institution: Tohoku University, Sendai, Japan, 2011

Research Description

Role of PPARgamma in the endothelium

Award(s)

  • Received a Caroline tum Suden/Frances Hellebrandt Professional Opportunity Travel Award, attend Experimental Biology Conference, Boston, MA, 2013
  • Annual High Blood Pressure Research Conference Travel Award for New Investigators (Returned), 2013

Publication(s)

  1. Agbor LN, Ibeawuchi SC, Hu C, Wu J, Davis DR, Keen HL, Quelle FW, Sigmund CD.:  Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism. JCI Insight 1(19):e91015, 2016.  PMCID: PMC5111503​​
  2. Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD.:  Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress.. Am J Physiol Heart Circ Physiol 319(1):H39-48, 2016.  PMCID: PMC4796462
  3. Hu C, Lu KT, Mukohda M, Davis DR, Faraci FM, Sigmund CD.:  Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction. 48(2):124-34, 2016.  PMCID: PMC4729699
  4. ​Stump M, Mukohda M, Hu C, Sigmund CD.:  PPARγ Regulation in Hypertension and Metabolic Syndrome. Curr Hypertens Rep 17(12):89, 2015.  PMID: 26462805
  5. Chen X, Mori T, Guo Q, Hu C, Ohsaki Y, Yoneki Y, Zhu W, Jiang Y, Endo S, Nakayama K, Ogawa S, Nakayama M, Miyata T, and Ito S.: Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats. Hypertens Res. 36(4):361-367, 2013. PMCID: PMC3619051​
  6. ​Hu C, Mori T, Lu Y, Guo Q, Sun Y, Yoneki Y, Ohsaki Y, Nakamichi T, Oba I, Sato E, Ogawa S, Dickinson BC, Chang CJ, Miyata T, Sato H, and Ito S.: Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation. J Hypertens. 30(8):1620-31, 2012. PMID: 22688264
  7. Guo Q, Mori T, Jiang Y, Hu C, Ohsaki Y, Yoneki Y, Nakamichi T, Ogawa S, Sato H, and Ito S.: Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats. Hypertens Res. 35(1):48-54, 2012. PMCID: PMC3257041
  8. Guo Q, Mori T, Jiang Y, Hu C, Osaki Y, Yoneki Y, Sun Y, Hosoya T, Kawamata A, Ogawa S, Nakayama M, Miyata T, and Ito S.: Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague-Dawley rats. J Hypertens. 27(8):1664-71, 2009. PMID: 19531965
  9. Jin C, Hu C, Polichnowski A, Mori T, Skelton M, Ito S, and Cowley AW, Jr.: Effects of renal perfusion pressure on renal medullary hydrogen peroxide and nitric oxide production. Hypertension. 53(6):1048-53, 2009. PMCID: PMC2777807
  10. Mori T, Chen X, Hu C, Ohsaki Y, Zhu W., Yoneki Y, Guo Q, Nakamichi T, Hosoya T, Nagasawa T, Inoue H, Ogawa S, Nakayama M, and Ito S.: Effects of methylglyoxal on the progression of chronic kidney disease. Therapeutic Research. 29(11):1884-1886, 2008. (Article in Japanese)
  11. Nakamichi T, Mori T, Sato T, Yoneki Y, Endo S, Rahman M, Zhu W, Hu C, Hosoya T, Sugiura A, Sato H, and Ito S.: The role of oxidative stress in the progression of chronic Thy-1 nephritis. Therapeutic Research. 28(10):1929-1930, 2007. (Article in Japanese)    

People