Address: 2-340 BSB
Phone: (319) 335-8926
Email: masashi-mukoda@uiowa.edu
Mentor: Curt D. Sigmund, PhD
PhD Institution: Kitasato University, Aomori, Japan, 2012
Research Description
Role of Hypertension and CDK5 in Regulating PPARγ Activity
Awards
- Postdoctoroal Fellow poster award, Iowa Physiological Society Meeting, University of Iowa, Iowa City, IA, 2017
- APS Cardiovascular Section Research Recognition Award, 2017
- APS Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award (Declined), 2017
- Veterinary Science Young Investigator Award, 2016
- University of Iowa Postdoctoral Association (UIPDA) Travel Award, 2016
- Finalist in the 2016 Juan Carlos Romero and APS Water & Electrolyte Homeostasis Section Postdoctoral Research Recognition Award, 2016
- Selection of APSselect, The American Physiological Society, 2016
- Onsite trainee poster award in Hypertension Conference (Declined), 2015
- Annual Hypertension Conference Travel Awards for New Investigators, 2015
(Instead of New Investigator Awards for Japanese Fellows) - New Investigator Award, Annual High Blood Pressure Research Conference, 2014
- ASBMB Postdoctoral Travel Award, 2014
Research Interest
Molecular Mechanism of PPARg on Regulation of Inflammation and Vascular Tone in Vascular Smooth Muscle Study
Publications
- Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD.: Hypertension-causing mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-kB p65 in Vascular Smooth Muscle. Hypertension. 70(1):174-182, 2017. PMCID: PMC5472224 [Available on 2018-07-01]
- Stump M, Guo DF, Lu KT, Mukohda M, Cassell MD, Norris AW, Rahmouni K, Sigmund CD.: Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development. 157(11):4266-4275, 2016. PMCID: PMC5086539
- Stump M, Guo DF, Lu KT, Mukohda M, Liu X, Rahmouni K, Sigmund CD.: Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance. Physiol Genomics 48(7):491-501, 2016. PMCID: PMC4967222
- Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD.: Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress. Am J Physiol Heart Circ Physiol 319(1):H39-48, 2016. (HPSselect) PMCID: PMC4796462
- Hu C, Lu KT, Mukohda M, Davis DR, Faraci FM, Sigmund CD.: Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction. Physiol Genomics 48(2):124-34, 2016. PMCID: PMC4729699
- Stump M, Mukohda M, Hu C, Sigmund CD.: PPARγ Regulation in Hypertension and Metabolic Syndrome. Curr Hypertens Rep 17(12):89, 2015. PMID: 26462805
- Mukohda M, Morita T, Okada M, Hara Y, Yamawaki H.: Long-term methylglyoxal treatment causes endothelial dysfunction of rat isolated mesenteric artery. J Vet Med Sci. 75(2):151-7, 2013. PMID: 23018793
- Mukohda M, Okada M, Hara Y, Yamawaki H.: Methylglyoxal accumulation in arterial walls causes vascular contractile dysfunction in spontaneously hypertensive rats (Review). J Pharmacol Sci. 120(1):26-35, 2012. PMID: 22971844 (Review)
- Mukohda M, Okada M, Hara Y, Yamawaki H.: Exploring mechanisms of diabetes-related macrovascular complications: role of methylglyoxal, a metabolite of glucose on regulation of vascular contractility. J Pharmacol Sci. 118(3):303-10, 2012. PMID: 22333481
- Yamawaki H, Takahashi M, Mukohda M, Morita T, Okada M, Hara Y.: A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats. Biochem Biophys Res Commun. 418(4):676-81, 2012. PMID: 22293188
- Mukohda M, Morita T, Okada M, Hara Y, Yamawaki H.: Long-term methylglyoxal treatment impairs smooth muscle contractility in organ-cultured rat mesenteric artery. Pharmacol Res. 65(1):91-9, 2012. PMID: 21884795
- Mukohda M, Yamawaki H, Okada M, Hara Y.Hideyuki Yamawaki, Muneyoshi Okada, Yukio Hara.: Methylglyoxal augments angiotensin II-induced contraction in rat isolated carotid artery. J Pharmacol Sci. 114(4):390-8, 2010. PMID: 21076237
- Mukohda M, Ueno S, Kamibayashi M, Okada M, Yamawaki H, Hara Y.: Influences of organic solvents on CYPMPO-electron spin resonance spectra in in vitro radical generating systems. J Vet Med Sci. 72(12):1547-50, 2010. PMID: 20661003
- Yamawaki H, Tsubaki N, Mukohda M, Okada M, Hara Y.: Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels. Biochem Biophys Res Commun. 393(4):668-72, 2010. PMID: 20170632
- Mukohda M, Yamawaki H, Okada M, Hara Y.: Methylglyoxal enhances sodium nitroprusside-induced relaxation in rat aorta. J Pharmacol Sci. 112(2):176-83, 2010. PMID: 20168042
- Mukohda M, Yamawaki H, Nomura H, Okada M, Hara Y.: Methylglyoxal inhibits smooth muscle contraction in isolated blood vessels. J Pharmacol Sci. 109(2):305-10, 2009. PMID: 19202315
- Nomura H, Yamawaki H, Mukohda M, Okada M, Hara Y.: Mechanisms underlying pioglitazone-mediated relaxation in isolated blood vessel. J Pharmacol Sci. 108(3):258-65, 2008. PMID: 18987433
- Baden T, Yamawaki H, Saito K, Mukohda M, Okada M, Hara Y.: Telmisartan inhibits methylglyoxal-mediated cell death in human vascular endothelium. Biochem Biophys Res Commun. 22;373(2):253-7, 2008. PMID: 18565324