Address: 2-340 BSB
Phone: (319) 335-8926
Email: njotu-agbor@uiowa.edu
Mentor: Curt D. Sigmund, PhD
PhD Institution: University of New Mexico, 2012
Research Description
Identification and function of PPAR-γ and PPAR-γ target genes in the blood vessel
Awards
- Ranbir K. Bhatnagar Scholar Award, Department of Pharmacology, University of Iowa, 2017
- 1st place oral presentation, 4th Annual Abboud Cardiovascular Symposium, 2017
- APS Minority Travel Fellowship Award, Experimental Biology, 2016
- New Investigator Travel Award, attend High Blood Pressure Meeting, 2016
- New Investigator Travel Award, AHA Council of Hypertension, 2015, 2016
- NIH Research Training Grant, HL007171 (Postdoctoral T32), 2014-present
Research Interest
Role of Cullin3 in human hypertension
Publications
- Agbor, L.N., Ibeawuchi, S.C., Hu, C., Wu, J., Davis, D.R., Keen, H.L., Quelle, F.W. and Sigmund, C.D.: Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism. JCI Insight. 1(19):e91015, 2016. PMCID: PMC5111503
- Ibeawuchi, S.R., Agbor, L.N., Quelle, F.W., Sigmund, C.D.: Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. J Biol Chem 290(31):19208-17, 2015. PMCID: PMC4521042
- Agbor, L.N., Wiest, E.F., Rothe, M., Schunck, W.H., Walker, M.K.: Role of CYP1A1 in modulating the vascular and blood pressure benefits of omega-3 polyunsaturated fatty acids. J Pharmacol Exp Ther. 351(3):688-98, 2014. PMCID: PMC4244579
- Bentson, L.F., Agbor, V.A., Agbor, L.N., Lopez, A.C., Nfonsam, L.E., Bornstein, S.S., Handel, M.A. and Linder, C.C.: New point mutation in Golga3 causes multiple defects in spermatogenesis. Andrology. 1(3):440-50, 2013. PMCID: PMC4134951
- Agbor, L.N., Walsh, M.T., Boberg, J.R. and Walker, M.K.: Elevated blood pressure in CYP1A1 knockout mice is associated with reduced vasodilation to omega-3 polyunsaturated fatty acids. Toxicol Appl Pharmacol. 264(3):351-360, 2012. PMCID: PMC3494483
- Agbor, L.N., Elased, K.M. and Walker, M.K.: Endothelial cell-specific aryl hydrocarbon receptor knockout mice exhibit hypotension mediated, in part, by an attenuated angiotensin II responsiveness. Biochem Pharmacol. 82(5):514-23, 2011. PMCID: PMC3148414
- Zhang, N., Agbor, L.N., Scott, J.A., Zalobowski, T., Elased, K.M., Trujillo, A., Duke, M.S., Wolf, V., Walsh, M.T., Born, J.L., Felton, L.A., Wang, J., Wang, W., Kanagy, N.L. and Walker, M.K.: An activated renin-angiotensin system maintains normal blood pressure in aryl hydrocarbon receptor heterozygous mice but not in null mice. Biochem Pharmacol. 80(2):197-204, 2010. PMCID: PMC2867364
- Kopf, P.G., Scott, J.A., Agbor, L.N., Boberg, J.R., Elased, K.M., Huwe, J.K. and Walker, M.K.: Cytochrome P4501A1 is required for vascular dysfunction and hypertension induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 117(2):537-46, 2010. PMCID: PMC2940412
- Lund, A.K., Agbor, L.N., Zhang, N., Baker, A., Zhao, H., Fink, G.D., Kanagy, N.L. and Walker, M.K.: Loss of the aryl hydrocarbon receptor induces hypoxemia, endothelin-1, and systemic hypertension at modest altitude. Hypertension. 51(3):803-809, 2008. PMID: 18212270