Ume Salma Shaik Amjad, PhD

Address: 2-551 BSB
Phone: (319) 335-7663

Mentor: Dawn E. Quelle, Ph.D.

PhD Institution: University of Madras

Research Description

Molecular and biological studies of RABL6A, Ras and Akt-mTOR pathways in cancer development


  1. Maina PK, Shao P, Jia X, Liu Q, Umesalma S, Marin M, Long D Jr, Concepción-Román S, Qi HH.: Histone demethylase PHF8 regulates hypoxia signaling through HIF1α and H3K4me3. Biochim Biophys Acta. 1860(9):1002-1012, 2017.  PMID: 28734980
  2. Shao P, Liu Q, Maina K, Cui J, Li T, Umesalma S, Zhang W, and Qi H.: Histone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis. Nucleic Acids Research. 45(4):1687-1702, 2016.  PMCID: PMC5389682
  3. Umesalma S, Frederick Keith HF, Baumbach GL, Chan SL.:  Roles of Caveolin-1 in Angiotensin II-Induced Hypertrophy and Inward remodeling of Cerebral pial Arterioles. Hypertension. 67:623-629, 2016.  PMCID: PMC4752427 (Selected for Invited Editorial Commentary)
    New Insights Into Mechanisms Associated With Angiotensin II-Induced Vascular Hypertrophy and Remodeling. Didion SP. Hypertension. 67(3):501-3, 2016.
  4. Chan SL, Umesalma S, Baumbach GL.:  Epidermal Growth Factor Receptor Is Critical For Angiotensin II-Mediated Hypertrophy in Cerebral Arterioles. Hypertension. 65:806-812, 2015.  PMID: 25733240
  5. Umesalma S, Sudhandiran G.:  Beneficial influence of ellagic acid on biochemical indexes associated with experimentally induced colon carcinogenesis. JCRT-745-15. J Cancer Res Ther. 2015
  6. Umesalma S, Nagendraprabhu P, Sudhandiran G.:  Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells. Mol Cell Biochem. 399:303-313, 2015.  PMID: 25355159
  7. Amjad S, Umesalma S.:  Protective Effect of Centella asiatica against Aluminium-Induced Neurotoxicity in Cerebral Cortex, Striatum, Hypothalamus and Hippocampus of Rat Brain. J Mol Biomark Diagn. 6:212, 2015.
  8. Umesalma S, Nagendraprabhu P, Sudhandiran G.:  Antiproliferative and apoptotic-inducing potential of ellagic acid against 1,2-dimethyl hydrazine-induced colon tumorigenesis in Wistar rats. Mol Cell Biochem. 388:157-172, 2014.  PMID: 24281858
  9. Horman SR, Janas MM, Litterst C, Wang B, Macrae IJ, Sever MJ, Morrissey DV, Graves P, Luo B, Umesalma S, Qi HH, Miraglia LJ, Novina CD, Orth AP.:  Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets. Mol Cell. 50:356-367, 2013.  PMCID: PMC3654076
  10. Umesalma S, Sudhandiran G.:  Ellagic acid prevents rat colon carcinogenesis induced by 1, 2 dimethyl hydrazine through inhibition of AKT-phosphoinositide-3 kinase pathway. Eur J Pharmacol. 660:249-258, 2011.  PMID: 21463623
  11. Umesalma S, Sudhandiran G.:  Differential inhibitory effects of the polyphenol ellagic acid on inflammatory mediators NF-κB, iNOS, COX-2, TNF-α and IL-6 in 1, 2-dimethyl hydrazine-induced rat colon carcinogenesis. Basic Clin Pharmacol Toxicol. 107:650-655, 2010.  PMID: 20406206
  12. Umesalma S, Sudhandiran G.:  Chemomodulation of the antioxidative enzymes and peroxidative damage in the colon of 1, 2-dimethyl hydrazine-induced rats by ellagic acid. Phytother Res. 24:S114-S119, 2010.  PMID: 19827028
  13. Magendiramani V, Umesalma S, Kalayarasan S, Nagendraprabhu P, Arunkumar J, Sudhandiran G.:  S-allylcysteine attenuates renal injury by altering the expressions of iNOS and matrix metallo proteinase-2 during cyclosporine-induced nephrotoxicity in Wistar rats. J Appl Toxicol. 29:522-530, 2009.  PMID: 19391111