Chen Zhao, MD, PhD

Assistant Professor of Pathology

Contact Information

Primary Office: 1163 Medical Laboratories
Iowa City, IA 52242


MD, China Medical University, No. 92, Shenyang, P.R.C.
PhD, Keio University School of Medicine, Tokyo, Japan

Fellow, Department of Pharmacology and Cancer Biology, Duke University Medical Center
Resident, Department of Pathology and Laboratory Medicine, University of Rochester, NY
Fellow, Hematopathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, PA


Werner, M. T., Zhao, C., Zhang, Q. & Wasik, M. A. (2017). Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target. Blood, 129(7), 823-831. PMID: 27879258.

Li, F., He, B., Ma, X., Yu, S., Bhave, R. R., Lentz, S. R., Tan, K., Guzman, M. L., Zhao, C. & Xue, H. H. (2017). Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1. Cell stem cell, 21(3), 359-373.e5. PMID: 28844837.

Chen, Z., Wang, W., Cortes, J. E., Liu, E., Miranda, R. N., Zhao, C., Yuan, J., Lu, X., Yang, W., Ameri, M. D., Kantarjian, H. M., Medeiros, L. J. & Hu, S. (2016). Differential clinical and prognostic impact of myeloid sarcoma vs medullary myeloid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy. Blood cancer journal, 6, e418. PMID: 27152845.

Zhao, J., Zhao, J., Mangalam, A. K., Channappanavar, R., Fett, C., Meyerholz, D. K., Agnihothram, S., Baric, R. S., David, C. S. & Perlman, S. (2016). Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses. Immunity, 44(6), 1379-91. PMID: 27287409.

Xiu, Y., Xue, W. Y., Lambertz, A., Leidinger, M., Gibson-Corley, K. & Zhao, C. (2016). Constitutive Activation of NIK Impairs the Self-Renewal of Hematopoietic Stem/Progenitor Cells and Induces Bone Marrow Failure. Stem cells (Dayton, Ohio). PMID: 27733012.

Zhang, H., Hilton, M. J., Anolik, J. H., Welle, S. L., Zhao, C., Yao, Z., Li, X., Wang, Z., Boyce, B. F. & Xing, L. (2014). NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-?B. Journal of clinical investigation, 124(7), 3200-14. PMID: 24892805.

Xiu, Y., Xu, H., Zhao, C., Li, J., Morita, Y., Yao, Z., Xing, L. & Boyce, B. F. (2014). Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. The Journal of clinical investigation, 124(1), 297-310. PMID: 24316970.

Lento, W., Ito, T., Zhao, C., Harris, J. R., Huang, W., Jiang, C., Owzar, K., Piryani, S., Racioppi, L., Chao, N. & Reya, T. (2014). Loss of ß-catenin triggers oxidative stress and impairs hematopoietic regeneration. Genes & development, 28(9), 995-1004. PMID: 24788518.

Kurokawa, M., Ito, T., Yang, C. S., Zhao, C., Macintyre, A. N., Rizzieri, D. A., Rathmell, J. C., Deininger, M. W., Reya, T. & Kombluth, S. (2013). Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. Proceedings of the National Academy of Sciences, 110(6), 2300-2305. PMID: 23324740.

Venigalla, S., Zhao, C. & Miyamoto, H. (2013). Histopathologic features of atypical glands on prostate biopsy: nucleolar size is a predictor of subsequent detection of prostatic adenocarcinoma. Prostate, 73(4), 376-381. PMID: 22926960.

Zhao, C., Venigalla, S. & Miyamoto, H. (2012). Chronic inflammation on initial benign prostate biopsy is a negative predictor of subsequent cancer detection. Pathology international, 62(11), 774-776. PMID: 23121611.

Fereshteh, M., Ito, T., Kovacs, J. J., Zhao, C., Kwon, H. Y., Konuma, V., Chen, M., Lefkowitz, R. J. & Reya, T. (2012). ß-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proceedings of the National Academy of Sciences, 109(31), 12532-12537. PMID: 22773819.

Zhao, C., Xiu, Y., Ashton, J., Xing, L., Morita, Y., Jordan, C. T. & Boyce, B. F. (2012). Noncanonical NF-?B signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions. Stem cells, 30(4), 709-718. PMID: 22290873.

Dai, S. D., Wang, Y., Jiang, G. Y., Zhang, P. X., Dong, X. J., Wei, Q., Xu, H. T., Li, Q. C., Zhao, C. & Wang, E. H. (2010). Kaiso is expressed in lung cancer: its expression and localization is affected by p120ctn. Lung Cancer, 67(2), 205-215. PMID: 19615783.

Ito, T., Kwon, H. Y., Zimdahl, B., Congdon, K. L., Blum, J., Lento, W. E., Zhao, C., Lagoo, A., Gerrard, G., Foroni, L., Goldman, J., Goh, H., Kim, S. H., Kim, D. W., Chuah, C., Oehler, V. G., Radich, J. P., Jordan, C. T. & Reya, T. (2010). Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature, 466(7307), 765-768. PMID: 20639863.

Liu, Y., Dong, Q. Z., Zhao, Y., Dong, X. J., Miao, Y., Dai, S. D., Yang, Z. Q., Zhang, D., Wang, Y., Li, Q. C., Zhao, C. & Wang, E. H. (2009). P120-catenin isoforms 1A and 3A differently affect invasion and proliferation of lung cancer cells. Experimental cell research, 315(5), 890-898. PMID: 19150613.

Zhao, C., Chen, A., Jamieson, C. H., Fereshteh, M., Abrahamsson, A., Blum, J., Kwon, H. Y., Kim, J., Chute, J. P., Rizzieri, D., Munchhof, M., VanArsdale, T., Beachy, P. A. & Reya, T. (2009). Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature, 458(7239), 776-779. PMID: 19169242.

Liu, Y., Wang, Y., Zhang, Y., Miao, Y., Zhao, Y., Zhang, P. X., Jiang, G. Y., Zhang, J. Y., Han, Y., Lin, X. Y., Yang, L. H., Li, Q. C., Zhao, C. & Wang, E. H. (2009). Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer. Lung Cancer, 63(3), 375-382. PMID: 19162367.

Liu, Y., Li, Q. C., Miao, Y., Xu, H. T., Dai, S. D., Wei, Q., Dong, Q. Z., Dong, X. J., Zhao, Y., Zhao, C. & Wang, E. H. (2009). Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells. Cancer Science, 100(3), 441-448. PMID: 19154401.

Wei, Q., Zhao, Y., Yang, Z. Q., Dong, Q. Z., Dong, X. J., Han, Y., Zhao, C. & Wang, E. H. (2008). Disheveled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression. Lung Cancer, 62(2), 181-192. PMID: 18692936.

Kurokawa, M., Zhao, C., Reya, T. & Kombluth, S. (2008). Inhibition of apoptosome formation by suppression of Hsp90beta phosphorylation in tyrosine kinase-induced leukemias. Molecular and cellular biology, 28(17), 5494-5506. PMID: 18591256.

Congdon, K. L., Voermans, C., Ferguson, E. C., DiMascio, L. N., Ugoezwa, M., Zhao, C. & Reya, T. (2008). Activation of Wnt signaling in hematopoietic regeneration. Stem Cells, 26(5), 1202-2010. PMID: 18308947.

Zhao, C., Blum, J., Chen, A., Kwon, H. Y., Jung, S. H., Cook, J. M., Lagoo, A. & Reya, T. (2007). Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell, 12(6), 528-541. PMID: 18068630.

Wu, M., Kwon, H. Y., Rattis, F., Blum, J., Zhao, C., Ashkenazi, R., Jackson, T. L., Gaiano, N., Oliver, T. & Reya, T. (2007). Imaging hematopoietic precursor division in real time. Cell Stem Cell, 1(5), 541-554. PMID: 18345353.

Nishiwaki, T., Yamaguchi, T., Zhao, C., Amano, H., Hankenson, K. D., Bornstein, P., Toyama, Y. & Matsuo, K. (2006). Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1. Journal of bone and mineral research, 21(4), 596-604. PMID: 16598380.

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T. & Matsuo, K. (2006). Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell metabolism, 4(2), 111-121. PMID: 16890539.

Duncan, A. W., Rattis, F. M., DiMascio, L. N., Congdon, K. L., Pazianos, G., Zhao, C., Yoon, K., Cook, J. M., Willert, K., Gaiano, N. & Reya, T. (2005). Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nature immunology, 6(3), 314-322. PMID: 15665828.

Matsuo, K., Galson, D. L., Zhao, C., Peng, L., Laplace, C., Wang, K. Z., Backler, M. A., Amano, H., Aburatani, H., Ishikawa, H. & Wagner, E. F. (2004). Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. Journal of biological chemistry, 279(25), 26475-26480. PMID: 15073183.

Sano, M., Kikuchi, K., Zhao, C., Kobayashi, M., Nakanishi, Y. & Nemoto, N. (2004). Osteoclastogenesis in human breast carcinoma. Virchows Archiv, 444(5), 470-472. PMID: 15014987.

Zhao, C., Wang, E. (2004). Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. Cellular signalling, 16(3), 313-321. PMID: 14687661.

Zhao, C., Hashiguchi, A., Kondoh, K., Du, W., Hata, J. & Yamada, T. (2002). Exogenous expression of heat shock protein 90kDa retards the cell cycle and impairs the heat shock response. Experimental cell research, 275(2), 200-214. PMID: 11969290.

Ueno, K., Tanaka, M., Miyakoshi, K., Zhao, C., Shinmoto, H., Nishimura, G. & Yoshimura, Y. (2002). Prenatal diagnosis of atelosteogenesis type I at 21 weeks' gestation. Prenatal diagnosis, 22(12), 1071-1075. PMID: 12454961.

Zhao, C., Yamada, T., Kuramochi, S., Yamazaki, K., Mukai, M., Kameyama, K. & Hata, J. (2000). Two cases of ectopic hamartomatous thymoma. Virchows Archiv, 437(6), 643-647. PMID: 11193476.