Munir R. Tanas, MD

Portrait
Co-Leader, Sarcoma Multi-disciplinary Oncology Group and Molecular Epidemiology Research Core
Assistant Professor of Pathology

Contact Information

Primary Office: 106A Medical Research Center
25 S. Grand Avenue
Iowa City, IA 52242
319-335-6637

Education

BS, Biochemistry, Whitworth College, Spokane, WA
MD, University of Washington, Seattle, WA

Resident, Anatomic Pathology, University of Washington, Seattle, WA
Fellow, Surgical Pathology, University of Washington, Seattle, WA
Fellow, Bone and Soft Tissue Pathology, Cleveland Clinic, Cleveland, OH
Postdoctoral Fellow, Molecular Genetics, Cleveland Clinic, Cleveland, OH

Licensure and Certifications

Doctor of Medicine - State Medical Board of Ohio
Board Certification in Anatomic Pathology - American Board of Pathology

Research Summary

Activation and mechanism of action of TAZ (WWTR1) and YAP1 in cancer.

Publications

Buchakjian, M. R., Merritt, N. M., Moose, D. L., Dupuy, A. J., Tanas, M. R. & Henry, M. D. (2017). A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging. PloS one, 12(8), e0183469. PMID: 28841687.

Guseva, N. V., Jaber, O., Tanas, M. R., Stence, A. A., Sompallae, R., Schade, J., Fillman, A. N., Miller, B. J., Bossler, A. D. & Ma, D. (2017). Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novel USP6 fusions and upregulation of USP6 expression in aneurysmal bone cyst. Genes, chromosomes & cancer, 56(4), 266-277. PMID: 27910166.

Fullenkamp, C. A., Hall, S. L., Jaber, O. I., Pakalniskis, B. L., Savage, E. C., Savage, J. M., Ofori-Amanfo, G. K., Lambertz, A. M., Ivins, S. D., Stipp, C. S., Miller, B. J., Milhem, M. M. & Tanas, M. R. (2016). TAZ and YAP are frequently activated oncoproteins in sarcomas. Oncotarget. PMID: 27129148.

Tanas, M. R., Ma, S., Jadaan, F. O., Ng, C. K., Weigelt, B., Reis-Filho, J. S. & Rubin, B. P. (2015). Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein. Oncogene, [Epub ahead of print]. PMID: 25961935.

Patel, N. R., Salim, A. A., Sayeed, H., Sarabia, S. F., Hollingsworth, F., Warren, M., Jakacky, J., Tanas, M., Oliveira, A. M., Rubin, B. P., Lazar, A. J., López-Terrada, D. & Wang, W. L. (2015). Molecular characterization of epithelioid haemangioendotheliomas identifies novel WWTR1-CAMTA1 fusion variants. Histopathology. PMID: 25817592.

Bohman, S. L., Goldblum, J. R., Rubin, B. P., Tanas, M. R. & Billings, S. D. (2014). Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum. Pathology, 46(3), 199-204. PMID: 24614712.

Cheah, A. L., Billings, S. D., Goldblum, J. R., Carver, P., Tanas, M. Z. & Rubin, B. P. (2014). STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics. Pathology, 46(5), 389-95. PMID: 24977739.

Tanas, M. R., Sboner, A., Oliveira, A. M., Erickson-Johnson, M. R., Hespelt, J., Hanwright, P. J., Flanagan, J., Luo, Y., Fenwick, K., Natrajan, R., Mitsopoulos, C., Zvelebil, M., Hoch, B. L., Weiss, S. W., Debiec-Rychter, M., Sciot, R., West, R. B., Lazar, A. J., Ashworth, A., Reis-Filho, J. S., Lord, C. J., Gerstein, M. B., Rubin, M. A. & Rubin, B. P. (2011). Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma. Science translational medicine, 3(98), 98ra82. PMID: 21885404.

Tanas, M. R., Rubin, B. P., Montgomery, E. A., Turner, S. L., Cook, J. R., Tubbs, R. R., Billings, S. D. & Goldblum, J. R. (2010). Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases. Modern pathology, 23(1), 93-7. PMID: 19801966.

Tanas, M. R., Rubin, B. P., Tubbs, R. R., Billings, S. D., Downs-Kelly, E. & Goldblum, J. R. (2010). Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience. Archives of pathology & laboratory medicine, 134(12), 1797-803. PMID: 21128778.

Tanas, M. R., Goldblum, J. R. (2009). Fluorescence in situ hybridization in the diagnosis of soft tissue neoplasms: a review. Advances in anatomic pathology, 16(6), 383-91. PMID: 19851129.

Tanas, M. R., Sthapanachai, C., Nonaka, D., Melamed, J., Oliveiera, A. M., Erickson-Johnson, M. R. & Rubin, B. P. (2009). Pseudosarcomatous fibroblastic/myofibroblastic proliferation in perinephric adipose tissue adjacent to renal cell carcinoma: a lesion mimicking well-differentiated liposarcoma. Modern pathology, 22(9), 1196-1200. PMID: 19525929.

Tanas, M. R., Rubin, B. P. (2009). Malignant neuroectodermal tumor with melanocytic and rhabdomyoblastic differentiation. Rare tumors, 1(2), e26. PMID: 21139905.

Wolf, P. S., Flum, D. R., Tanas, M. R., Rubin, B. P. & Mann, G. N. (2008). Epithelioid sarcoma: the University of Washington experience. American journal of surgery, 196(3), 407-12. PMID: 18436180.

Rubin, B. P., Antonescu, C. R., Scott-Browne, J. P., Comstock, M. L., Gu, Y., Tanas, M. R., Ware, C. B. & Woodell, J. (2005). A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E. Cancer research, 65(15), 6631-9. PMID: 16061643..

Badjou, S., Powers, G. D. & Tanas, M. R. (1997). Proceedings. Ultrasonic Measurement of Postural Stability andControl. Tenth IEEE Symposium on Computer-based Medical Systems, 164-165.