Siegfried Janz, MD, DSc

Portrait
Endowed Professor in Cancer Research
Professor of Pathology

Contact Information

Primary Office: 2202 Medical Education Research Facility
Iowa City, IA 52242
319-384-2869

Education

Diploma, Master of Medicine, University of Leipzig Medical School
MD, University of Leipzig Medical School
DSc, University of Leipzig Medical School

Resident, Clinical Immunology, University of Leipzig Medical School, Germany

Licensure and Certifications

Clinical Immunologist - Leipzig, Saxony, Germany
Physician - Leipzig, Saxony, Germany

Education/Training Program Affiliations

Interdisciplinary Graduate Program in Immunology, Medical Scientist Training Program

Center, Program and Institute Affiliations

Holden Comprehensive Cancer Center

Research Summary

Molecular genetics of B cell and plasma cell neoplasms.

Publications

Hao, M., Machin, R. F., Xu, H., Shaughnessy, J., Barlogie, B., Roodman, D., Quelle, D. E., Janz, S., Tomasson, M. H., Sanderson, R. D., Qiu, L., Frech, I., Tricot, G. & Zhan, F. (2017). NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma. Leukemia. PMID: 28400617.

Janz, S. (2016). Mouse model of MYD88L265P-dependent DLBCL. Blood, 127(22), 2660-1. PMID: 27257177.

Rabellino, A., Melegari, M., Tompkins, V. S., Chen, W., Van Ness, B. G., Teruya-Feldstein, J., Conacci-Sorrell, M., Janz, S. & Scaglioni, P. P. (2016). PIAS1 Promotes Lymphomagenesis through MYC Upregulation. Cell reports. PMID: 27239040.

Rosean, T. R., Holman, C. J., Tompkins, V. S., Jing, X., Krasowski, M. D., Rose-John, S. & Janz, S. (2016). KSHV-encoded vIL-6 collaborates with deregulated c-Myc to drive plasmablastic neoplasms in mice. Blood cancer journal, 6, e398. PMID: 26918362.

Tompkins, V. S., Sompallae, R., Rosean, T. R., Walsh, S., Acevedo, M., Kovalchuk, A. L., Han, S. S., Jing, X., Holman, C., Rehg, J. E., Herms, S., Sunderland, J. S., Morse, H. C. & Janz, S. (2016). Transgenic mouse model of IgM<sup>+</sup> lymphoproliferative disease mimicking Waldenström macroglobulinemia. Blood cancer journal, 6(11), e488. PMID: 27813533.

Gu, C., Yang, Y., Sompallae, R., Xu, H., Tompkins, V. S., Holman, C., Hose, D., Goldschmidt, H., Tricot, G., Zhan, F. & Janz, S. (2015). FOXM1 is a therapeutic target for high-risk multiple myeloma. Leukemia. PMID: 26648534.

Franqui-Machin, R., Wendlandt, E. B., Janz, S., Zhan, F. & Tricot, G. (2015). Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction?. Oncotarget. PMID: 26415231.

Zhang, L., Blackwell, K., Workman, L. M., Chen, S., Pope, M. R., Janz, S. & Habelhah, H. (2015). RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-?B Activation and Lymphoma Survival. Molecular and cellular biology, 35(19), 3324-38. PMID: 26195820.

Yang, Y., Shi, J., Gu, Z., Salama, M. E., Das, S., Wendlandt, E., Xu, H., Huang, J., Tao, Y., Hao, M., Franqui, R., Levasseur, D., Janz, S., Tricot, G. & Zhan, F. (2015). Bruton tyrosine kinase is a therapeutic target in stem-like cells from multiple myeloma. Cancer research, 75(3), 594-604. PMID: 25589346.

Rosean, T. R., Tompkins, V. S., Olivier, A. K., Sompallae, R., Norian, L. A., Morse, H. C., Waldschmidt, T. J. & Janz, S. (2015). The tumor microenvironment is the main source of IL-6 for plasma cell tumor development in mice. Leukemia, 29(1), 233-7. PMID: 25257990.

Han, S. S., Tompkins, V. S., Son, D. J., Han, S., Yun, H., Kamberos, N. L., Dehoedt, C. L., Gu, C., Holman, C., Tricot, G., Zhan, F. & Janz, S. (2015). CDKN1A and FANCD2 are potential oncotargets in Burkitt lymphoma and multiple myeloma. Experimental hematology & oncology, 4, 9. PMID: 25838973.

Yang, Y., Zhou, W., Xia, J., Gu, Z., Wendlandt, E., Zhan, X., Janz, S., Tricot, G. & Zhan, F. (2014). NEK2 mediates ALDH1A1 induced drug-resistance in multiple myeloma. Oncotarget, [Epub ahead of print]. PMID: 25230277.

Rosean, T. R., Tompkins, V. S., Tricot, G., Holman, C. J., Olivier, A. K., Zhan, F. & Janz, S. (2014). Preclinical validation of interleukin 6 as a therapeutic target in multiple myeloma. Immunologic research [Epub ahead of print]. PMID: 24845460.

Reed, S. M., Hagen, J., Muniz, V. P., Rosean, T. R., Borcherding, N., Sciegienka, S., Goeken, J. A., Naumann, P. W., Zhang, W., Tompkins, V. S., Janz, S., Meyerholz, D. K. & Quelle, D. E. (2014). NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas. PLoS One, 9(11), e112126. PMID: 25393878.

Stessman, H. A., Mansoor, A., Zhan, F., Janz, S., Linden, M. A., Baughn, L. B. & Van Ness, B. (2013). Reduced CXCR4 expression is associated with extramedullary disease in a mouse model of myeloma and predicts poor survival in multiple myeloma patients treated with bortezomib. Leukemia, 27(10), 2075-2077. PMID: 23728080.

Tompkins, V. S., Han, S. S., Olivier, A., Syrbu, S., Bair, T., Button, A., Jacobus, L., Wang, Z., Lifton, S., Raychaudhuri, P., Morse, H. C., Weiner, G., Link, B., Smith, B. J. & Janz, S. (2013). Identification of candidate B-lymphoma genes by cross-species gene expression profiling. PLoS One, 8(10), e76889. PMID: 24130802.

Zhou, W., Yang, Y., Gu, Z., Wang, H., Xia, J., Wu, X., Zhan, X., Levasseur, D., Zhou, Y., Janz, S., Tricot, G., Shi, J. & Zhan, F. (2013). ALDH1 activity identifies tumor-initiating cells and links to chromosomal instability signatures in multiple myeloma. Leukemia [epub ahead of print]. PMID: 24365790.

Duncan, K., Rosean, T. R., Tompkins, V. S., Olivier, A., Sompallae, R., Zhan, F., Tricot, G., Acevedo, M. R., Ponto, L. L., Walsh, S. A., Tygrett, L. T., Berger, A. J., Waldschmidt, T. J., Morse, H. C., Sunderland, J. J. & Janz, S. (2013). (18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib. Blood Cancer Journal, 3, e165. PMID: 24292417.

Han, S. S., Tompkins, V. S., Son, D. J., Kamberos, N. L., Stunz, L. L., Halwani, A., Bishop, G. A. & Janz, S. (2013). Piperlongumine inhibits LMP1/MYC-dependent mouse B-lymphoma cells. Biochemical and biophysical research communications, 436(4), 660-5. PMID: 23764397.

Stessman, H. A., Baughn, L. B., Sarver, A., Xia, T., Deshpande, R., Mansoor, A., Walsh, S. A., Sunderland, J. J., Dolloff, N. G., Linden, M. A., Zhan, F., Janz, S., Myers, C. L. & Van Ness, B. G. (2013). Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model. Molecular cancer therapeutics, 12(6), 1140-50. PMID: 23536725.

Han, S. S., Son, D. J., Yun, H., Kamberos, N. L. & Janz, S. (2013). Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro. Leukemia research, 37(2), 146-54. PMID: 23237561.

Janz, S. (2013). Waldenström Macroglobulinemia: Clinical and Immunological Aspects, Natural History, Cell of Origin, and Emerging Mouse Models. ISRN hematology [eCollection], 815325. PMID: 24106612.

Janz, S., Bommert, K. S., Effenberger, M., Leich, E., Küspert, M., Murphy, D., Langer, C., Moll, R., Janz, S., Mottok, A., Weissbach, S., Rosenwald, A., Bargou, R. & Bommert, K. (2012). The feed-forward loop between YB-1 and MYC is essential for multiple myeloma cell survival. Leukemia, 27(2), 441-450. PMID: 22772059.

Suthaus, J., Stuhlmann-Laeisz, C., Tompkins, V. S., Rosean, T. R., Klapper, W., Tosato, G., Janz, S., Scheller, J. & Rose-John, S. (2012). HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice. Blood, 119(22), 5173-81. PMID: 22490805.

LeGrand, J., Park, E. S., Wang, H., Gupta, S., Owens, J. D., Nelson, P. J., DuBois, W., Bair, T., Janz, S. & Mushinski, J. F. (2012). Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia. Blood, 119(4), 1018-28. PMID: 22147894.

Janz, S., Qi, C. F., Kim, Y. S., Xiang, S., Abdullaev, Z., Torrey, T. A., Janz, S., Kovalchuk, A. L., Sun, J., Chen, D., Cho, W. C., Gu, W. & Morse, H. C. (2012). Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms. International journal of molecular sciences, 13(5), 6204-19. PMID: 22754359.

Berger, A., Manfredi, M. G., Bolen, J., Janz, S., Lee, E. C., Fitzgerald, M., Bannerman, B., Donelan, J., Bano, K., Terkelsen, J., Bradley, D. P., Subakan, O., Silva, M. D., Liu, R., Pickard, M., Li, Z., Tayber, O., Li, P., Hales, P., Carsillo, M., Neppalli, V. T., Berger, A. J., Kupperman, E., Manfredi, M., Bolen, J. B., Van Ness, B. & Janz, S. (2011). Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research, 17(23), 7313-23. PMID: 21903769.

Takizawa, M., Kim, J. S., Tessarollo, L., McNeil, N., Waldschmidt, T. J., Casellas, R., Ried, T. & Janz, S. (2010). Genetic reporter system for oncogenic Igh-Myc translocations in mice. Oncogene, 29(28), 4113-20. PMID: 20453890.

Zingone, A., Cultraro, C. M., Shin, D. M., Bean, C. M., Morse, H. C., Janz, S. & Kuehl, W. M. (2010). Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms. Leukemia, 24(6), 1171-8. PMID: 20393505.

Han, S. S., Yun, H., Son, D. J., Tompkins, V. S., Peng, L., Chung, S. T., Kim, J. S., Park, E. S. & Janz, S. (2010). NF-kB/STAT3/PI3K signaling crosstalk in iMyc E mu B lymphoma. Molecular cancer, 9, 97. PMID: 20433747.

Rutsch, S., Neppalli, V. T., Shin, D. M., DuBois, W., Morse, H. C., Goldschmidt, H. & Janz, S. (2010). IL-6 and MYC collaborate in plasma cell tumor formation in mice. Blood, 115(9), 1746-54. PMID: 20018915.

de Jong, D., Janz, S. (2010). Anaplastic plasmacytoma of mouse-establishing parallels between subtypes of mouse and human plasma cell neoplasia. The Journal of pathology, 221(3), 242-7. PMID: 20527018.

Janz, S., Dolken, G., Schüler, F., Dölken, L., Hirt, C., Kiefer, T., Berg, T., Fusch, G., Weitmann, K., Hoffmann, W., Fusch, C., Janz, S., Rabkin, C. S. & Dölken, G. (2009). Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals. International journal of cancer, 124(4), 958-63. PMID: 19030176.

Rabkin, C. S., Janz, S. (2008). Mechanisms and consequences of chromosomal translocation. Cancer epidemiology, biomarkers & prevention, 17(8), 1849-51. PMID: 18708370.

Rabkin, C. S., Hirt, C., Janz, S. & Dölken, G. (2008). t(14;18) Translocations and risk of follicular lymphoma. Journal of the National Cancer Institute - Monographs,(39), 48-51. PMID: 18648003.

Rabkin, C. S., Janz, S. (2008). Overview of mechanisms and consequences of chromosomal translocation. Journal of the National Cancer Institute. Monographs,(39), 1. PMID: 18647992.

Janz, S. (2008). Genetic and environmental cofactors of Myc translocations in plasma cell tumor development in mice. Journal of the National Cancer Institute - Monographs,(39), 37-40. PMID: 18648000.

Khuda, S. E., Loo, W. M., Janz, S., Van Ness, B. & Erickson, L. D. (2008). Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors. Journal of immunology, 181(11), 7537-49. PMID: 19017943.

Yan, Y., Park, S. S., Janz, S. & Eckhardt, L. A. (2007). In a model of immunoglobulin heavy-chain (IGH)/MYC translocation, the Igh 3' regulatory region induces MYC expression at the immature stage of B cell development. Genes, chromosomes & cancer, 46(10), 950-9. PMID: 17639584.

Janz, S., Crouch, E. E., Li, Z., Takizawa, M., Fichtner-Feigl, S., Gourzi, P., Montaño, C., Feigenbaum, L., Wilson, P., Janz, S., Papavasiliou, F. N. & Casellas, R. (2007). Regulation of AID expression in the immune response. The Journal of experimental medicine, 204(5), 1145-56. PMID: 17452520.

Janz, S., Park, E. S., Shaughnessy, J. D., Gupta, S., Wang, H., Lee, J. S., Woo, H. G., Zhan, F., Owens, J. D., Potter, M., Janz, S. & Mushinski, J. F. (2007). Gene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia. BMC genomics, 8, 302. PMID: 17764563.

Hirt, C., Dölken, G., Janz, S. & Rabkin, C. S. (2007). Distribution of t(14;18)-positive, putative lymphoma precursor cells among B-cell subsets in healthy individuals. British journal of haematology, 138(3), 349-53. PMID: 17614821.

Fujita, K., Janz, S. (2007). Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF. Molecular cancer, 6, 71. PMID: 17971207.

Janz, S., Ried, M., Kovalchuk, A. L., duBois, W., Mushinski, E., McNeil, N. E., Hirt, C., Qi, C. F., Li, Z., Janz, S., Honjo, T., Muramatsu, M., Ried, T., Behrens, T. & Potter, M. (2007). AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements. The Journal of experimental medicine, 204(12), 2989-3001. PMID: 17998390.

Boylan, K. L., Gosse, M. A., Staggs, S. E., Janz, S., Grindle, S., Kansas, G. S. & Van Ness, B. G. (2007). A transgenic mouse model of plasma cell malignancy shows phenotypic, cytogenetic, and gene expression heterogeneity similar to human multiple myeloma. Cancer research, 67(9), 4069-78. PMID: 17483317.

Janz, S., Qi, C. F., Zhou, J. X., Lee, C. H., Naghashfar, Z., Xiang, S., Kovalchuk, A. L., Fredrickson, T. N., Hartley, J. W., Roopenian, D. C., Davidson, W. F., Janz, S. & Morse, H. C. (2007). Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells. Cancer research, 67(6), 2439-47. PMID: 17363561.

Janz, S. (2006). TCL1-Induced Germinal Center B Lymphomas in Mice. Blood (Inside Capsule), 108(6), 1791-1792.

Kim, J. S., Han, S. S., Park, S. S., McNeil, N. & Janz, S. (2006). Plasma cell tumour progression in iMycEmu gene-insertion mice. The Journal of pathology, 209(1), 44-55. PMID: 16482495.

Janz, S. (2006). Distinct MYC Thresholds in Hematopoietic Neoplasia. Blood (Inside Capsule), 108(2), 413.

Han, S. S., Peng, L., Chung, S. T., DuBois, W., Maeng, S. H., Shaffer, A. L., Sporn, M. B. & Janz, S. (2006). CDDO-Imidazolide inhibits growth and survival of c-Myc-induced mouse B cell and plasma cell neoplasms. Molecular cancer, 5, 22. PMID: 16759389.

Silva, S., Wiener, F., Klein, G. & Janz, S. (2005). Location of Myc, Igh, and Igk on Robertsonian fusion chromosomes is inconsequential for Myc translocations and plasmacytoma development in mice, but Rb(6.15)-carrying tumors prefer Igk-Myc inversions over translocations. Genes, chromosomes & cancer, 42(4), 416-26. PMID: 15645495.

Janz, S., Han, S. S., Shaffer, A. L., Peng, L., Chung, S. T., Lim, J. H., Maeng, S., Kim, J. S., McNeil, N., Ried, T., Staudt, L. M. & Janz, S. (2005). Molecular and cytological features of the mouse B-cell lymphoma line iMycEmu-1. Molecular cancer, 4, 40. PMID: 16277667.

Park, S. S., Kim, J. S., Tessarollo, L., Owens, J. D., Peng, L., Han, S. S., Tae Chung, S., Torrey, T. A., Cheung, W. C., Polakiewicz, R. D., McNeil, N., Ried, T., Mushinski, J. F., Morse, H. C. & Janz, S. (2005). Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice. Cancer research, 65(4), 1306-15. PMID: 15735016.

Park, S. S., Shaffer, A. L., Kim, J. S., duBois, W., Potter, M., Staudt, L. M. & Janz, S. (2005). Insertion of Myc into Igh accelerates peritoneal plasmacytomas in mice. Cancer research, 65(17), 7644-52. PMID: 16140930.

Zhu, D., Qi, C. F., Morse, H. C., Janz, S. & Stevenson, F. K. (2005). Deregulated expression of the Myc cellular oncogene drives development of mouse "Burkitt-like" lymphomas from naive B cells. Blood, 105(5), 2135-7. PMID: 15522957.

McNeil, N., Kim, J. S., Ried, T. & Janz, S. (2005). Extraosseous IL-6 transgenic mouse plasmacytoma sometimes lacks Myc-activating chromosomal translocation. Genes, chromosomes & cancer, 43(2), 137-46. PMID: 15751044.

Felix, K., Gerstmeier, S., Kyriakopoulos, A., Howard, O. M., Dong, H. F., Eckhaus, M., Behne, D., Bornkamm, G. W. & Janz, S. (2004). Selenium deficiency abrogates inflammation-dependent plasma cell tumors in mice. Cancer research, 64(8), 2910-7. PMID: 15087411.

Felix, K., Polack, A., Pretsch, W., Jackson, S. H., Feigenbaum, L., Bornkamm, G. W. & Janz, S. (2004). Moderate hypermutability of a transgenic lacZ reporter gene in Myc-dependent inflammation-induced plasma cell tumors in mice. Cancer research, 64(2), 530-7. PMID: 14744766.

Cheung, W. C., Kim, J. S., Linden, M., Peng, L., Van Ness, B., Polakiewicz, R. D. & Janz, S. (2004). Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. The Journal of clinical investigation, 113(12), 1763-73. PMID: 15199411.

Rockwood, L. D., Felix, K. & Janz, S. (2004). Elevated presence of retrotransposons at sites of DNA double strand break repair in mouse models of metabolic oxidative stress and MYC-induced lymphoma. Mutation research, 548(2-Jan), 117-25. PMID: 15063142.

Felix, K., Rolink, A., Melchers, F. & Janz, S. (2003). Bcl-2 reduces mutant rates in a transgenic lacZ reporter gene in mouse pre-B lymphocytes. Mutation research, 522(2-Jan), 135-44. PMID: 12517419.

Silva, S., Kovalchuk, A. L., Kim, J. S., Klein, G. & Janz, S. (2003). BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations. Cancer research, 63(24), 8656-63. PMID: 14695177.

Felix, K., Rockwood, L. D., Pretsch, W., Bornkamm, G. W. & Janz, S. (2003). Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase. Free radical biology & medicine, 34(2), 226-32. PMID: 12521604.

Rockwood, L. D., Nussenzweig, A. & Janz, S. (2003). Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair. Mutation research, 529(2-Jan), 51-8. PMID: 12943919.

Kovalchuk, A. L., Kim, J. S. & Janz, S. (2003). E mu/S mu transposition into Myc is sometimes a precursor for T(12;15) translocation in mouse B cells. Oncogene, 22(18), 2842-50. PMID: 12743607.

Hausmann, M., Winkler, R., Hildenbrand, G., Finsterle, J., Weisel, A., Rapp, A., Schmitt, E., Janz, S. & Cremer, C. (2003). COMBO-FISH: specific labeling of nondenatured chromatin targets by computer-selected DNA oligonucleotide probe combinations. BioTechniques, 35(3), 564-70, 572-7. PMID: 14513562.

Felix, K., Rockwood, L. D., Pretsch, W., Nair, J., Bartsch, H., Bornkamm, G. W. & Janz, S. (2002). Moderate G6PD deficiency increases mutation rates in the brain of mice. Free radical biology & medicine, 32(7), 663-73. PMID: 11909700.

Kovalchuk, A. L., Janz, S. (2002). Isotype switch-mediated CH deletions are a recurrent feature of Myc/CH translocations in peritoneal plasmacytomas in mice. International journal of cancer, 101(5), 423-6. PMID: 12216069.

Kovalchuk, A. L., Kim, J. S., Park, S. S., Coleman, A. E., Ward, J. M., Morse, H. C., Kishimoto, T., Potter, M. & Janz, S. (2002). IL-6 transgenic mouse model for extraosseous plasmacytoma. Proceedings of the National Academy of Sciences of the United States of America, 99(3), 1509-14. PMID: 11805288.

Kovalchuk, A. L., Esa, A., Coleman, A. E., Park, S. S., Ried, T., Cremer, C. C. & Janz, S. (2001). Translocation remodeling in the primary BALB/c plasmacytoma TEPC 3610. Genes, chromosomes & cancer, 30(3), 283-91. PMID: 11170286.

Hori, M., Xiang, S., Qi, C. F., Chattopadhyay, S. K., Fredrickson, T. N., Hartley, J. W., Kovalchuk, A. L., Bornkamm, G. W., Janz, S., Copeland, N. G., Jenkins, N. A., Ward, J. M. & Morse, H. C. (2001). Non-Hodgkin lymphomas of mice. Blood cells, molecules & diseases, 27(1), 217-22. PMID: 11358382.

Felix, K., Kovalchuk, A. L., Park, S. S., Coleman, A. E., Ramsay, E. S., Qian, M., Kelliher, K. A., Jones, G. M., Ried, T., Bornkamm, G. W. & Janz, S. (2001). Inducible mutagenesis in TEPC 2372, a mouse plasmacytoma cell line that harbors the transgenic shuttle vector lambdaLIZ. Mutation research, 473(1), 121-36. PMID: 11166031.

Esa, A., Coleman, A. E., Edelmann, P., Silva, S., Cremer, C. G. & Janz, S. (2001). Conformational differences in the 3-D nanostructure of the immunoglobulin heavy-chain locus, a hotspot of chromosomal translocations in B lymphocytes. Cancer genetics and cytogenetics, 127(2), 168-73. PMID: 11425458.

Kovalchuk, A. L., Mushinski, E. B. & Janz, S. (2000). Clonal diversification of primary BALB/c plasmacytomas harboring T(12;15) chromosomal translocations. Leukemia, 14(5), 909-21. PMID: 10803525.

Kovalchuk, A. L., Kishimoto, T. & Janz, S. (2000). Lymph nodes and Peyer's patches of IL-6 transgenic BALB/c mice harbor T(12;15) translocated plasma cells that contain illegitimate exchanges between the immunoglobulin heavy-chain mu locus and c-myc. Leukemia, 14(6), 1127-35. PMID: 10865979.

Coleman, A. E., Ried, T. & Janz, S. (2000). Chromosomes 1 and 5 harbor plasmacytoma progressor genes in mice. Genes, chromosomes & cancer, 29(1), 70-4. PMID: 10918396.

Kovalchuk, A. L., Qi, C. F., Torrey, T. A., Taddesse-Heath, L., Feigenbaum, L., Park, S. S., Gerbitz, A., Klobeck, G., Hoertnagel, K., Polack, A., Bornkamm, G. W., Janz, S. & Morse, H. C. (2000). Burkitt lymphoma in the mouse. The Journal of experimental medicine, 192(8), 1183-90. PMID: 11034608.

Coleman, A. E., Kovalchuk, A. L., Janz, S., Palini, A. & Ried, T. (1999). Jumping translocation breakpoint regions lead to amplification of rearranged Myc. Blood, 93(12), 4442-4. PMID: 10391697.

Felix, K., Kelliher, K. A., Bornkamm, G. W. & Janz, S. (1999). Elevated mutant frequencies in lymphoid tissues persist throughout plasmacytoma development in BALB/c.lambdaLIZ mice. Cancer research, 59(15), 3621-6. PMID: 10446972.

Coleman, A. E., Forest, S. T., McNeil, N., Kovalchuk, A. L., Ried, T. & Janz, S. (1999). Cytogenetic analysis of the bipotential murine pre-B cell lymphoma, P388, and its derivative macrophage-like tumor, P388D1, using SKY and CGH. Leukemia, 13(10), 1592-600. PMID: 10516761.

Felix, K., Lin, S., Bornkamm, G. W. & Janz, S. (1998). Tetravinyl-tetramethylcyclo-tetrasiloxane (tetravinyl D4) is a mutagen in Rat2lambda lacI fibroblasts. Carcinogenesis, 19(2), 315-20. PMID: 9498283.

Felix, K., Kelliher, K., Bornkamm, G. W. & Janz, S. (1998). Association of elevated mutagenesis in the spleen with genetic susceptibility to induced plasmacytoma development in mice. Cancer research, 58(8), 1616-9. PMID: 9563470.

Müller, J. R., Jones, G. M., Janz, S. & Potter, M. (1997). Migration of cells with immunoglobulin/c-myc recombinations in lymphoid tissues of mice. Blood, 89(1), 291-6. PMID: 8978304.

Rabkin, C. S., Janz, S., Lash, A., Coleman, A. E., Musaba, E., Liotta, L., Biggar, R. J. & Zhuang, Z. (1997). Monoclonal origin of multicentric Kaposi's sarcoma lesions. The New England journal of medicine, 336(14), 988-93. PMID: 9077377.

Coleman, A. E., Schröck, E., Weaver, Z., du Manoir, S., Yang, F., Ferguson-Smith, M. A., Ried, T. & Janz, S. (1997). Previously hidden chromosome aberrations in T(12;15)-positive BALB/c plasmacytomas uncovered by multicolor spectral karyotyping. Cancer research, 57(20), 4585-92. PMID: 9377573.

Felix, K., Lin, S. & Janz, S. (1997). Elevated mutant frequencies in gene lacI in splenic lipopolysaccharide blasts after exposure to activated phagocytes in vitro. European journal of immunology, 27(9), 2160-4. PMID: 9341754.

Felix, K., Potter, M., Bornkamm, G. W. & Janz, S. (1997). In vitro mutagenicity of the plasmacytomagenic agent pristane (2,6,10,14-tetramethylpentadecane). Cancer letters, 113(2-Jan), 71-6. PMID: 9065804.

Kovalchuk, A. L., Müller, J. R. & Janz, S. (1997). Deletional remodeling of c-myc-deregulating chromosomal translocations. Oncogene, 15(19), 2369-77. PMID: 9393881.

Müller, J. R., Mushinski, E. B., Jones, G. M., Williams, J. A., Janz, S., Hausner, P. F. & Potter, M. (1997). Generation of immunoglobulin/c-myc recombinations in murine Peyer's patch follicles. Current topics in microbiology and immunology, 224, 251-5. PMID: 9308248.

Kovalchuk, A. L., Potter, M. & Janz, S. (1996). DNA sequence analysis of the genetic recombination between Igh6 and Myc in an uncommon BALB/c plasmacytoma, TEPC 1194. Immunogenetics, 44(2), 151-6. PMID: 8662079.

Liyanage, M., Coleman, A., du Manoir, S., Veldman, T., McCormack, S., Dickson, R. B., Barlow, C., Wynshaw-Boris, A., Janz, S., Wienberg, J., Ferguson-Smith, M. A., Schröck, E. & Ried, T. (1996). Multicolour spectral karyotyping of mouse chromosomes. Nature genetics, 14(3), 312-5. PMID: 8896561.

Müller, J. R., Jones, G. M., Potter, M. & Janz, S. (1996). Detection of immunoglobulin/c-myc recombinations in mice that are resistant to plasmacytoma induction. Cancer research, 56(2), 419-23. PMID: 8542601.

Janz, S., Roschke, V. V. (1996). Completion of the DNA sequence determination of the Igh2 locus of the mouse: the 5'-IA region. Immunogenetics, 43(2-Jan), 101-4. PMID: 8537111.

Müller, J. R., Janz, S., Goedert, J. J., Potter, M. & Rabkin, C. S. (1995). Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men. Proceedings of the National Academy of Sciences of the United States of America, 92(14), 6577-81. PMID: 7604036.

Janz, S., Gawrisch, K. & Lester, D. S. (1995). Translocation and activation of protein kinase C by the plasma cell tumor-promoting alkane pristane. Cancer research, 55(3), 518-24. PMID: 7834620.

Janz, S., Jones, G. M., Müller, J. R. & Potter, M. (1995). Genomic instability in B-cells and diversity of recombinations that activate c-myc. Current topics in microbiology and immunology, 194, 373-80. PMID: 7895512.

Janz, S., Shacter, E. (1995). Disposition of the plasmacytomagenic alkane pristane (2,6,10,14-tetramethylpentadecane) in mice. Cancer biochemistry biophysics, 15(1), 25-34. PMID: 8536217.

Müller, J. R., Janz, S. & Potter, M. (1995). Differences between Burkitt's lymphomas and mouse plasmacytomas in the immunoglobulin heavy chain/c-myc recombinations that occur in their chromosomal translocations. Cancer research, 55(21), 5012-8. PMID: 7585544.

Müller, J., Janz, S. (1994). In vitro cytotoxicity of neutrophil-like human HL-60 cells undergoing an oxidative burst with Escherichia coli reporter strains. Toxicology in vitro, 8(3), 437-40. PMID: 20692935.

Janz, S., Shacter, E. & Herrmann, A. (1994). Fusion between enveloped viruses and erythrocyte membranes is induced by the isoprenoid alkane pristane (2,6,10,14-tetramethylpentadecane). Cancer biochemistry biophysics, 14(1), 14-Jan. PMID: 7796384.

Müller, J. R., Potter, M. & Janz, S. (1994). Differences in the molecular structure of c-myc-activating recombinations in murine plasmacytomas and precursor cells. Proceedings of the National Academy of Sciences of the United States of America, 91(25), 12066-70. PMID: 7991585.

Raabe, F., Janz, S., Wolff, G., Merten, H., Landrock, A., Birkenfeld, T. & Herzschuh, R. (1993). Genotoxicity assessment of waste products of aluminum plasma etching with the SOS chromotest. Mutation research, 300(2), 99-109. PMID: 7685499.

Müller, J., Janz, S. (1993). Modulation of the H2O2-induced SOS response in Escherichia coli PQ300 by amino acids, metal chelators, antioxidants, and scavengers of reactive oxygen species. Environmental and molecular mutagenesis, 22(3), 157-63. PMID: 8404875.

Janz, S., Müller, J., Shaughnessy, J. & Potter, M. (1993). Detection of recombinations between c-myc and immunoglobulin switch alpha in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction. Proceedings of the National Academy of Sciences of the United States of America, 90(15), 7361-5. PMID: 8346257.

Janz, S., Shacter, E. (1993). Activated murine neutrophils induce unscheduled DNA synthesis in B lymphocytes. Mutation research, 293(2), 173-86. PMID: 7678145.

Janz, S., Krumbiegel, M. & Gawrisch, K. (1992). The fluidity of DOPC bilayers and membrane fractions prepared from murine plasmacytoma cells is unchanged after incorporation of pristane (2,6,10,14-tetramethylpentadecane) as assessed by fluorescence polarization analysis. Cancer biochemistry biophysics, 13(2), 85-92. PMID: 1343851.

Müller, J., Janz, S. (1992). Assessment of oxidative DNA damage in the oxyR-deficient SOS chromotest strain Escherichia coli PQ300. Environmental and molecular mutagenesis, 20(4), 297-306. PMID: 1425609.

Gawrisch, K., Janz, S. (1991). The uptake of pristane (2,6,10,14-tetramethylpentadecane) into phospholipid bilayers as assessed by NMR, DSC, and tritium labeling methods. Biochimica et biophysica acta, 1070(2), 409-18. PMID: 1764453.

Muller, J., Brede, O. & Janz, S. (1991). A Gamma-Radiolysis Study on the Potential Involvement of a Genotoxic Metabolite in Pristane Induced Plasmacytomagenesis. Central Institute of Isotope and Radiation Research Press, Leipzig, Germany,(5th), 131-137.

Janz, S., Brede, O. & Müller, J. (1991). The reaction of pristane (2,6,10,14-tetramethylpentadecane) with radiolytically generated reactive oxygen intermediates results in a stable genotoxic compound as assessed by the SOS chromotest. Carcinogenesis, 12(7), 1241-6. PMID: 2070489.

Janz, S., Shacter, E. (1991). A new method for delivering alkanes to mammalian cells: preparation and preliminary characterization of an inclusion complex between beta-cyclodextrin and pristane (2,6,10,14-tetramethylpentadecane). Toxicology, 69(3), 301-15. PMID: 1949053.

Raabe, F., Janz, S. & Wolff, G. (1990). The effect of non-ionic surfactants on the SOS-inducing potency of 4-nitroquinoline-1-oxide in Escherichia coli PQ37. Journal of basic microbiology, 30(6), 435-42. PMID: 2126282.

Shacter, E., Lopez, R. L., Beecham, E. J. & Janz, S. (1990). DNA damage induced by phorbol ester-stimulated neutrophils is augmented by extracellular cofactors. Role of histidine and metals. The Journal of biological chemistry, 265(12), 6693-9. PMID: 2157707.

Janz, S., Raabe, F. & Wolff, G. (1990). Application of an alternative approach for using the SOS chromotest to screen complex indeterminate mixtures. Zentralblatt für Mikrobiologie, 145(3), 177-82. PMID: 2196748.

Janz, S., Wolff, G., Huttunen, T., Raabe, F. & Storch, H. (1989). Quantitation of the relationship between tester cell number inoculated and SOS-inducing potency of 4-nitroquinoline-1-oxide (4-NQO) in an automated version of the SOS chromotest. Journal of basic microbiology, 29(7), 403-11. PMID: 2513384.

Janz, S., Rassmann, B., Raabe, F. & Storch, H. (1989). Histologic studies of paraproteinemic nephropathy in BALB/c mice with mineral oil-induced plasmacytoma. Zeitschrift für Urologie und Nephrologie, 82(12), 671-8. PMID: 2629422.

Janz, S., Birkenfeld, T., Herzschuh, R. & Storch, H. (1989). Gas chromatographic-mass spectrometric investigation of four commercial pristane (2.6.10.14-tetramethylpentadecane) preparations used for plasmacytoma induction in BALB/c mice. Archiv für Geschwulstforschung, 59(6), 415-22. PMID: 2596957.

Klimm, W., Janz, S. & Gabert, A. (1989). Experimental research on the genotoxicity of various root canal antiseptics in the SOS chromotest. Zahn-, Mund-, und Kieferheilkunde mit Zentralblatt, 77(2), 128-30. PMID: 2526434.

Janz, S., Wolff, G. & Storch, H. (1988). SOS chromotest, a quantitative short-term bacterial assay for the detection of genotoxic compounds in an automated version adapted to Bioscreen Analyzer System. Zentralblatt für Mikrobiologie, 143(8), 645-9. PMID: 3149098.

Janz, S., Huttunen, T., Herzschuh, R. & Storch, H. (1988). Genotoxicity assessment of the plasmacytomagenic agent pristane (2.6.10.14-tetramethylpentadecane) and four related alkanes by the SOS chromotest. Archiv für Geschwulstforschung, 58(2), 73-8. PMID: 3288166.

Janz, S., Herzschuh, R. & Storch, H. (1987). Evidence for high purity of a commercial pristane (2,6,10,14-tetramethylpentadecane) preparation used for plasmocytoma induction in BALB/c mice. Experimental pathology, 31(4), 253-5. PMID: 3622726.

Janz, S., Püschel, W., Raabe, F. & Storch, H. (1987). Induction of plasma cell tumours with 2,6,10,14-tetramethylpentadecane (pristane) and paraffin oil (paraffinum perliquidum) in BALB/c mice simultaneously exposed to sustained antigenic stimulation with bovine serum albumin (BSA). Archiv für Geschwulstforschung, 57(1), 25-30. PMID: 3566462.