Selvakumar Govindhasamy Pushpavathi, PhD

Address: 2-400 BSB
Phone: (319) 335-7769
Email: gp-selvakumar@uiowa.edu

Mentor: Catherine Marcinkiewcz, PhD

PhD Institution: Annamalai University, Tamil Nadu, India, 2015

Research Description

The role of dorsal raphe serotonergic circuits in neuropsychiatric disorders and Alzheimer's disease

Publications

  1. Nagalakshmi Balasubramanian, Thomas D James, Govindhasamy Pushpavathi Selvakumar, Catherine A. Marcinkiewcz. Repeated ethanol exposure and withdrawal alters ACE2 expression in discrete brain regions: Implications for SARS-CoV-2 infection. bioRxiv 2022.03.29. 486282; doi: https://doi.org/10.1101/2022.03.29.486282. Submitted to Alcoholism: Clinical and Experimental Research.

  2. Kanza M. Khan, Govindhasamy Pushpavathi Selvakumar, Nagalakshmi Balasubramanian, Ruixiang Wang, Samantha Pierson, Marco Hefti, Catherine A Marcinkiewcz. Behavioral dysregulation and monoaminergic deficits precede memory impairments in human tau-overexpressing (htau) mice. bioRxiv 2022.04.03.486898; doi: https://doi.org/10.1101/2022.04.03. 486898. Submitted to Acta Neuropathologica Communication.

  3. Kanza M. Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Selvakumar GP, Suzanne Mason, Michael E. Dailey, Catherine A. Marcinkiewcz. Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood. doi: https://doi.org/10.1101/2021.11.29.469930. Submitted to Brain Behavior Immunity. Submitted on Nov, 2021.

  4. Selvakumar GP, Ahmed ME, Iyer SS, Thangavel R, Kempuraj D, Raikwar SP, Bazley K, Wu K, Khan A, Kukulka K, Bussinger B, Zaheer S, Burton C, James D, Zaheer A. Absence of Glia Maturation Factor Protects from Axonal Injury and Motor Behavioral Impairments after Traumatic Brain Injury. Exp Neurobiol. 2020 Jun 30;29(3):230-248. doi: 10.5607/en20017.PMID: 32565489.

  5. Selvakumar GP, Ahmed ME, Thangavel R, Kempuraj D, Dubova I, Raikwar SP, Zaheer S, Iyer SS, Zaheer A. A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice. Brain Behav Immun. 2020 Jul;87:429-443. doi: 10.1016/j.bbi.2020.01.013. Epub 2020 Jan 23. PMID: 31982500

  6. Kempuraj D, Thangavel R, Kempuraj DD, Ahmed ME, Selvakumar GP, Raikwar SP, Zaheer SA, Iyer SS, Govindarajan R, Chandrasekaran PN, Zaheer A. Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma. Biofactors. 2020 Oct 24. doi: 10.1002/biof.1687. Online ahead of print. PMID: 33098588 Review.

  7. Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Govindarajan R, Nattanmai Chandrasekaran P, Burton C, James D, Zaheer A. Acute Traumatic Brain Injury-Induced Neuroinflammatory Response and Neurovascular Disorders in the Brain. Neurotox Res. 2020 Sep 21:1-10. doi: 10.1007/s12640-020-00288-9. Online ahead of print. PMID: 32955722.

  8. Raikwar SP, Thangavel R, Ahmed ME, Selvakumar GP, Kempuraj D, Wu K, Khan O, Bazley K, Bussinger B, Kukulka K, Zaheer S, Iyer SS, Govindarajan R, Burton C, James D, Zaheer A. Real- Time Noninvasive Bioluminescence, Ultrasound and Photoacoustic Imaging in NFκB-RE-Luc Transgenic Mice Reveal Glia Maturation Factor-Mediated Immediate and Sustained Spatio- Temporal Activation of NFκB Signaling Post-Traumatic Brain Injury in a Gender-Specific Manner. Cell Mol Neurobiol. 2020 Aug 12. doi: 10.1007/s10571-020-00937-9. Online ahead of print.PMID: 32785863

  9. Mehta T, Fayyaz M, Giler GE, Kaur H, Raikwar SP, Kempuraj D, Selvakumar GP, Ahmed ME, Thangavel R, Zaheer S, Iyer S, Govindarajan R, Zaheer A. Current Trends in Biomarkers for Traumatic Brain Injury. Open Access J Neurol Neurosurg. 2020;12(4):86-94. Epub 2020 Jan 8.PMID: 32775958

  10. Ahmed ME, Selvakumar GP, Kempuraj D, Raikwar SP, Thangavel R, Bazley K, Wu K, Khan O, Khan A, Zaheer S, Iyer S, Burton C, James D, Zaheer A. Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain Injury. Mol Neurobiol. 2020 Nov;57(11):4438-4450. doi: 10.1007/s12035-020- 02040-y. Epub 2020 Jul 31.PMID: 32737763

  11. Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Burton C, James D, Zaheer A. Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain Injury. Mediators Inflamm. 2020 Jun 24;2020:4243953. doi: 10.1155/2020/4243953. eCollection 2020.PMID: 32684835.

  12. Kempuraj D, Selvakumar GP, Ahmed ME, Raikwar SP, Thangavel R, Khan A, Zaheer SA, Iyer SS, Burton C, James D, Zaheer A. COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation. Neuroscientist. 2020 Oct-Dec;26(5-6):402-414. doi: 10.1177/1073858420941476. Epub 2020 Jul 18.PMID: 32684080 Review.

  13. Ahmed ME, Selvakumar GP, Thangavel R, Kempuraj D, Raikwar SP, Zaheer S, Iyer S, Zaheer A. Immune Suppression of Glia Maturation Factor Reverses Behavioral Impairment, Attenuates Amyloid Plaque Pathology and Neuroinflammation in an Alzheimer's Disease Mouse Model. J Neuroimmune Pharmacol. 2020 Jun 5. doi: 10.1007/s11481-020-09929-4. Online ahead of print.PMID: 32504312

  14. Javed H, Thangavel R, Selvakumar GP, Dubova I, Schwartz N, Ahmed ME, Zaheer S, Kempuraj D, Iyer S, Zaheer A, Khan MM. NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson's disease. Int Immunopharmacol. 2020 Jun;83:106441. doi: 10.1016/j.intimp.2020.106441. Epub 2020 Apr 4.PMID: 32259702

  15. Ahmed ME, Selvakumar GP, Kempuraj D, Raikwar SP, Thangavel R, Bazley K, Wu K, Khan O, Kukulka K, Bussinger B, Dubova I, Zaheer S, Govindarajan R, Iyer S, Burton C, James D, Zaheer A. Neuroinflammation Mediated by Glia Maturation Factor Exacerbates Neuronal Injury in an in vitro Model of Traumatic Brain Injury. J Neurotrauma. 2020 Jul 15;37(14):1645-1655. doi: 10.1089/neu.2019.6932. Epub 2020 Apr 17.PMID: 32200671

  16. Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Burton C, James D, Zaheer A. Psychological Stress-Induced Immune Response and Risk of Alzheimer's Disease in Veterans from Operation Enduring Freedom and Operation Iraqi Freedom. Clin Ther. 2020   Jun;42(6):974-982.   doi:   10.1016/j.clinthera.2020.02.018.  Epub   2020   Mar  14.PMID: 32184013 Free PMC article. Review.

  17. Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Dhaliwal AS, Dubova I, Mentor S, Premkumar K, Saeed D, Zahoor H, Raikwar SP, Zaheer S, Iyer SS, Zaheer A. Brain Injury-Mediated Neuroinflammatory Response and Alzheimer's Disease. Neuroscientist. 2020 Apr;26(2):134-155. doi: 10.1177/1073858419848293. Epub 2019 May 16.PMID: 31092147.

  18. Raikwar SP, Kikkeri NS, Sakuru R, Saeed D, Zahoor H, Premkumar K, Mentor S, Thangavel R, Dubova I, Ahmed ME, Selvakumar GP, Kempuraj D, Zaheer S, Iyer SS, Zaheer A. Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders. J Neuroimmune Pharmacol. 2019 Dec;14(4):608-641. doi: 10.1007/s11481-019-09849-y. Epub 2019 Apr 23.PMID: 31011884 Review.

  19. Ahmed ME, Selvakumar GP, Kempuraj D, Thangavel R, Mentor S, Dubova I, Raikwar SP, Zaheer S, Iyer S, Zaheer A. Synergy in Disruption of Mitochondrial Dynamics by Aβ (1-42) and Glia Maturation Factor (GMF) in SH-SY5Y Cells Is Mediated Through Alterations in Fission and Fusion Proteins. Mol Neurobiol. 2019 Oct;56(10):6964-6975. doi: 10.1007/s12035-019-1544-z. Epub 2019 Apr 4.PMID: 30949973

  20. Kempuraj D, Mentor S, Thangavel R, Ahmed ME, Selvakumar GP, Raikwar SP, Dubova I, Zaheer S, Iyer SS, Zaheer A. Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer's Disease. Front Cell Neurosci. 2019 Feb 19;13:54. doi: 10.3389/fncel.2019.00054. eCollection 2019.PMID: 30837843

  21. Ramaswamy SB,  Bhagavan  SM,  Kaur  H,  Giler  GE,  Kempuraj  D,  Thangavel  R,  Ahmed  ME, Selvakumar GP, Raikwar SP, Zaheer S, Iyer SS, Govindarajan R, Zaheer A. Glia Maturation Factor in the Pathogenesis of Alzheimer's disease. Open Access J Neurol Neurosurg. 2019;12(3):79- 82. Epub 2019 Dec 17.PMID: 32775957

  22. Selvakumar GP, Ahmed ME, Raikwar SP, Thangavel R, Kempuraj D, Dubova I, Saeed D, Zahoor H, Premkumar K, Zaheer S, Iyer S, Zaheer A. CRISPR/Cas9 Editing of Glia Maturation Factor Regulates Mitochondrial Dynamics by Attenuation of the NRF2/HO-1 Dependent Ferritin Activation in Glial Cells. J Neuroimmune Pharmacol. 2019 Feb 27. doi: 10.1007/s11481-019- 09833-6.

  23. Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer's Disease. Kempuraj D, Mentor S, Thangavel R, Ahmed ME, Selvakumar GP, Raikwar SP, Dubova I, Zaheer S, Iyer SS, Zaheer A. Front Cell Neurosci. 2019 Feb 19;13:54. doi: 10.3389/fncel.2019.00054. eCollection 2019.

  24. Raikwar SP, Thangavel R, Dubova I, Ahmed ME, Selvakumar PG, Kempuraj D, Zaheer  S, Iyer S, Zaheer A. Neuro-Immuno-Gene- and Genome-Editing-Therapy for Alzheimer's Disease: Are We There Yet? J Alzheimers Dis. 2018;65(2):321-344. doi: 10.3233/JAD-180422.

  25. Kempuraj D, Selvakumar GP, Thangavel R, Ahmed ME, Zaheer S, Kumar KK, Yelam A, Kaur H, Dubova I, Raikwar SP, Iyer SS, Zaheer A. Glia Maturation Factor and Mast Cell-Dependent Expression of Inflammatory Mediators and Proteinase Activated Receptor-2 in Neuroinflammation. J Alzheimers Dis. 2018;66(3):1117-1129. doi: 10.3233/JAD-180786. PMID: 30372685

  26. Selvakumar GP, Iyer SS, Kempuraj D, Ahmed ME, Thangavel R, Dubova I, Raikwar SP, Zaheer S, Zaheer A. Molecular Association of Glia Maturation Factor with the Autophagic Machinery in Rat Dopaminergic Neurons: a Role for Endoplasmic Reticulum Stress and MAPK Activation. Mol Neurobiol. 2018 Sep 14. doi: 10.1007/s12035-018-1340-1. [Epub ahead of print] PMID: 30218400

  27. Kempuraj D, Thangavel R, Selvakumar GP, Ahmed ME, Zaheer S, Raikwar SP, Zahoor H, Saeed D, Dubova I, Giler G, Herr S, Iyer SS, Zaheer A. Mast Cell Proteases Activate Astrocytes and Glia- Neurons and Release Interleukin-33 by Activating p38 and ERK1/2 MAPKs and NF-κB. Mol Neurobiol. 2018 Jun 18. doi: 10.1007/s12035-018-1177-7. [Epub ahead of print] PMID: 29916143

  28. Raikwar SP, Bhagavan SM, Ramaswamy SB, Thangavel R, Dubova I, Selvakumar GP, Ahmed ME, Kempuraj D, Zaheer S, Iyer S, Zaheer A. Are Tanycytes the Missing Link Between Type 2 Diabetes and Alzheimer's Disease? Mol Neurobiol. 2018 May24. 10.1007/s12035-018-1123-8. [Epub ahead of print] Review. PMID: 29797185

  29. Raikwar SP, Thangavel R, Dubova I, Selvakumar GP, Ahmed ME, Kempuraj D, Zaheer SA, Iyer SS, Zaheer A. Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer's Disease Therapeutic Target. Mol Neurobiol. 2018 Apr 27. doi: 10.1007/s12035-018-1068-y. [Epub ahead of print] PMID: 29704201

  30. Selvakumar GP, Iyer SS, Kempuraj D, Raju M, Thangavel R, Saeed D, Ahmed ME, Zahoor H, Raikwar SP, Zaheer S, Zaheer A. Glia Maturation Factor Dependent Inhibition of Mitochondrial PGC-1α Triggers Oxidative Stress-Mediated Apoptosis in N27 Rat Dopaminergic Neuronal Cells. Mol Neurobiol. 2018 Sep;55(9):7132-7152. doi: 10.1007/s12035-018-0882-6. Epub 2018 Jan 30. PMID: 29383690

  31. Kempuraj D, Selvakumar GP, Thangavel R, Ahmed ME, Zaheer S, Raikwar SP, Iyer SS, Bhagavan SM, Beladakere-Ramaswamy S, Zaheer A. Mast Cell Activation in Brain Injury, Stress, and Post- traumatic Stress Disorder and Alzheimer's Disease Pathogenesis. Front Neurosci. 2017 Dec 12;11:703. doi: 10.3389/fnins.2017.00703. eCollection 2017. Review. PMID: 29302258

  32. Thangavel R, Bhagavan SM, Ramaswamy SB, Surpur S, Govindarajan R, Kempuraj D, Zaheer S, Raikwar S, Ahmed ME, Selvakumar GP, Iyer SS, Zaheer A. Co-Expression of Glia Maturation Factor and Apolipoprotein E4 in Alzheimer's Disease Brain. J Alzheimers Dis. 2018;61(2):553-560. doi: 10.3233/JAD-170777. PMID: 29172001

  33. Ahmed ME, Iyer S, Thangavel R, Kempuraj D, Selvakumar GP, Raikwar SP, Zaheer S, Zaheer A. Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer's Disease Brain. J Alzheimers Dis. 2017;60(3):1143-1160. doi: 10.3233/JAD-170634. PMID: 28984607

  34. Kempuraj D, Selvakumar GP, Zaheer S, Thangavel R, Ahmed ME, Raikwar S, Govindarajan R, Iyer S, Zaheer A. Cross-Talk between Glia, Neurons and Mast Cells in Neuroinflammation Associated with Parkinson's Disease. J Neuroimmune Pharmacol. 2018 Mar;13(1):100-112. doi: 10.1007/s11481-017-9766-1. Epub 2017 Sep 26. PMID: 28952015

  35. Kempuraj D, Thangavel R, Selvakumar GP, Zaheer S, Ahmed ME, Raikwar SP, Zahoor H, Saeed D, Natteru PA, Iyer S, Zaheer A. Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration. Front Cell Neurosci. 2017 Jul 24;11:216. doi: 10.3389/fncel.2017.00216. eCollection 2017. Review. PMID: 28790893

  36. Thangavel R, Kempuraj D, Zaheer S, Raikwar S, Ahmed ME, Selvakumar GP, Iyer SS, Zaheer A. Glia Maturation Factor and Mitochondrial Uncoupling Proteins 2 and 4 Expression in the Temporal Cortex of Alzheimer's Disease Brain. Front Aging Neurosci. 2017 May 18;9:150. doi: 10.3389/fnagi.2017.00150. eCollection 2017. PMID: 28572767

  37. Kempuraj D, Thangavel R, Natteru PA, Selvakumar GP, Saeed D, Zahoor H, Zaheer S, Iyer SS, Zaheer A. Neuroinflammation Induces Neurodegeneration. J Neurol Neurosurg Spine. 2016;1(1). pii: 1003. Epub 2016 Nov 18. PMID: 28127589

  38. Selvakumar GP, Manivasagam T, Rekha KR, Jayaraj RL, Elangovan N. Escin, a novel triterpene, mitigates chronic MPTP/p-induced dopaminergic toxicity by attenuating mitochondrial dysfunction, oxidative stress, and apoptosis. J Mol Neurosci. 2015 Jan;55(1):184-197. doi: 10.1007/s12031-014- 0303-x. Epub 2014 May 2. PMID: 24788336

  39. Rekha KR, Selvakumar GP. Gene expression regulation of Bcl2, Bax and cytochrome-C by geraniol on chronic MPTP/probenecid induced C57BL/6 mice model of Parkinson's disease. Chem Biol Interact. 2014 Jun 25;217:57-66. doi: 10.1016/j.cbi.2014.04.010. Epub 2014 Apr 24. PMID: 24768735

  40. Selvakumar GP, Janakiraman U, Essa MM, Justin Thenmozhi A, Manivasagam T. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease. Brain Res. 2014 Oct 17;1585:23-36. doi: 10.1016/j.brainres.2014.03.010. Epub 2014 Mar 20. PMID: 24657313

  41. Kavitha M, Manivasagam T, Essa MM, Tamilselvam K, Selvakumar GP, Karthikeyan S, Thenmozhi JA, Subash S. Mangiferin antagonizes rotenone: induced apoptosis through attenuating mitochondrial dysfunction and oxidative stress in SK-N-SH neuroblastoma cells. Neurochem Res. 2014 Apr;39(4):668-76. doi: 10.1007/s11064-014-1249-7. Epub 2014 Feb 4. PMID: 24493626

  42. Rekha KR, Selvakumar GP, Santha K, Inmozhi Sivakamasundari R. Geraniol attenuates α- synuclein expression and neuromuscular impairment through increase dopamine content in MPTP intoxicated mice by dose dependent manner. Biochem Biophys Res Commun. 2013 Nov 1;440(4):664-70. doi: 10.1016/j.bbrc.2013.09.122. Epub 2013 Oct 5. PMID: 24103762

  43. Rekha KR, Selvakumar GP, Sethupathy S, Santha K, Sivakamasundari RI. Geraniol ameliorates the motor behavior and neurotrophic factors inadequacy in MPTP-induced mice model of Parkinson's disease. J Mol Neurosci. 2013 Nov;51(3):851-62. doi: 10.1007/s12031-013-0074-9. Epub 2013 Aug 13. PMID: 23943375

  44. Karamkolly Raghavan Rekha, Govindasamy Pushpavathi Selvakumar, Ramu Inmozhi Sivakamasundari. Effects of syringic acid on chronic MPTP/probenecid induced motor dysfunction, dopaminergic markers expression and neuroinflammation in C57BL/6 mice. Biomedicine & Aging Pathology. 2014;4: 95–104. (Elseiver).

 

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