– Newly Added Paper

June 30

• A Pilot Study of Preoperative Vandetanib on Markers of Proliferation and Apoptosis in Breast Cancer.  Spanheimer PM, Bashir A, Lorenzen AW, Beck AC, Liao J, Lizarraga IM, Erdahl LM, Sugg SL, Karwal MW, Weigel RJ. Am J Clin Oncol. 2021 Jun 30. doi: 10.1097/COC.0000000000000845. Online ahead of print. PMID: 34190716
• CGRP induces migraine-like symptoms in mice during both the active and inactive phases.  Wattiez AS, Gaul OJ, Kuburas A, Zorilla E, Waite JS, Mason BN, Castonguay WC, Wang M, Robertson BR, Russo AF. J Headache Pain. 2021 Jun 30;22(1):62. doi: 10.1186/s10194-021-01277-9. PMID: 34193048
• Four evolving concepts in molecular and clinical autonomic research. Abboud FM. Clin Auton Res. 2021 Jun 30. doi: 10.1007/s10286-021-00816-3. Online ahead of print. PMID: 34191210.
• Polycythemia is Associated with Lower Incidence of Severe COPD Exacerbations in SPIROMICS Study. Fawzy A, Woo H, Balasubramanian A, Barjaktarevic I, Barr RG, Bowler RP, Comellas AP, Cooper CB, Couper D, Criner GJ, Dransfield MT, Han MK, Hoffman EA, Kanner RE, Krishnan JA, Martinez FJ, McCormack M, Paine Iii R, Peters S, Wise R, Woodruff PG, Hansel NN, Putcha N. Chronic Obstr Pulm Dis. 2021 Jun 30. doi: 10.15326/jcopdf.2021.0216. Online ahead of print. PMID: 34197703
• Vascular Effects of Disrupting Endothelial mTORC1 (Mechanistic Target of Rapamycin Complex 1) Signaling in Obesity.  Reho JJ, Guo DF, Beyer AM, Wegman-Points L, Pierce GL, Rahmouni K. Am J Physiol Regul Integr Comp Physiol. 2021 Jun 30. doi: 10.1152/ajpregu.00113.2021. Online ahead of print. PMID: 34189960

June 29

• Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Gitelman SE, Bundy BN, Ferrannini E, Lim N, Blanchfield JL, DiMeglio LA, Felner EI, Gaglia JL, Gottlieb PA, Long SA, Mari A, Mirmira RG, Raskin P, Sanda S, Tsalikian E, Wentworth JM, Willi SM, Krischer JP, Bluestone JA; Gleevec Trial Study Group. Lancet Diabetes Endocrinol. 2021 Jun 29:S2213-8587(21)00139-X. doi: 10.1016/S2213-8587(21)00139-X. Online ahead of print. PMID: 34214479

June 28

• Adherence to Recommended Eating Patterns Is Associated With Lower Risk of Peripheral Arterial Disease: Results From the Women's Health Initiative.  Chen GC, Arthur R, Mossavar-Rahmani Y, Xue X, Haring B, Shadyab AH, Allison MA, Liu S, Tinker LF, Saquib N, Coday M, Shikany JM, Neuhouser ML, Snetselaar LG, Van Horn L, Rohan TE, Wassertheil-Smoller S, Kaplan RC, Qi Q. Hypertension. 2021 Jun 28:HYPERTENSIONAHA12117432. doi: 10.1161/HYPERTENSIONAHA.121.17432. Online ahead of print. PMID: 34176290
• Outcomes of peroral endoscopic myotomy in patients with achalasia and prior bariatric surgery: A multicenter experience.  Bomman S, Klair JS, Ashat M, El Abiad R, Gerke H, Keech J, Parekh K, Nau P, Hanada Y, Wong Kee Song LM, Kozarek R, Irani S, Low D, Ross A, Krishnamoorthi R. Dis Esophagus. 2021 Jun 28:doab044. doi: 10.1093/dote/doab044. Online ahead of print. PMID: 34184036

June 26

• Exome-based investigation of the genetic basis of human pigmentary glaucoma. van der Heide C, Goar W, Meyer KJ, Alward WLM, Boese EA, Sears NC, Roos BR, Kwon YH, DeLuca AP, Siggs OM, Gonzaga-Jauregui C, Sheffield VC, Wang K, Stone EM, Mullins RF, Anderson MG, Fan BJ, Ritch R, Craig JE, Wiggs JL, Scheetz TE, Fingert JH. BMC Genomics. 2021 Jun 26;22(1):477. doi: 10.1186/s12864-021-07782-0.PMID: 34174832.

June 25

• Early Lung Disease Exhibits Bacterial-Dependent and -Independent Abnormalities in Cystic Fibrosis Pigs.  Bouzek DC, Abou Alaiwa MH, Adam RJ, Pezzulo AA, Reznikov LR, Cook DP, Aguilar Pescozo MI, Ten Eyck P, Wu C, Gross TJ, Hornick DB, Hoffman EA, Meyerholz DK, Stoltz DA. Am J Respir Crit Care Med. 2021 Jun 25. doi: 10.1164/rccm.202102-0451OC. Online ahead of print. PMID: 34170795

June 24

• Case Studies in Physiology: Temporal Variations of the Lung Parenchyma and Vasculature in Asymptomatic COVID-19 Pneumonia: A Multi-Spectral CT Assessment.  Nagpal P, Motahari A, Gerard SE, Guo J, Reinhardt JM, Comellas AP, Hoffman EA, Kaczka DW. J Appl Physiol (1985). 2021 Jun 24. doi: 10.1152/japplphysiol.00147.2021. Online ahead of print. PMID: 34166081
• COVID-19 Admission Screening, and Assessment of Infectiousness at an Academic Medical Center, Iowa 2020.  Alsuhaibani M, Kobayashi T, Trannel A, Holley S, Abosi OJ, Jenn KE, Meacham H, Sheeler L, Etienne W, Dains A, Kukla ME, Ward E, Ford B, Edmond MB, Wellington M, Diekema DJ, Salinas JL. Infect Control Hosp Epidemiol. 2021 Jun 24:1-19. doi: 10.1017/ice.2021.294. Online ahead of print. PMID: 34169812
• Inflammatory cytokines TNFα and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators.  Rehman T, Karp PH, Tan P, Goodell BJ, Pezzulo AA, Thurman AL, Thornell IM, Durfey SL, Duffey ME, Stoltz DA, McKone EF, Singh PK, Welsh MJ. J Clin Invest. 2021 Jun 24:150398. doi: 10.1172/JCI150398. Online ahead of print. PMID: 34166230
• Molecular epidemiology of large coronavirus disease 2019 (COVID-19) clusters before and after the implementation of routine serial testing at an academic medical center in Iowa, 2020.  Ortiz ME, Kobayashi T, Imborek K, Alsuhaibani M, Holley S, Trannel A, Marra AR, Etienne W, Jenn KE, Abosi OJ, Meacham H, Sheeler L, Dains A, Kukla ME, McCray PB, Perlman S, Ford B, Diekema DJ, Wellington M, Pezzulo AA, Salinas JL.Infect Control Hosp Epidemiol. 2021 Jun 24:1-3. doi: 10.1017/ice.2021.301. Online ahead of print. PMID: 34229775

June 23

• Radiation-induced Hounsfield unit change correlates with dynamic CT perfusion better than 4DCT-based ventilation measures in a novel-swine model.  Wuschner AE, Wallat EM, Flakus MJ, Shanmuganayagam D, Meudt J, Christensen GE, Reinhardt JM, Miller JR, Lawless MJ, Baschnagel AM, Bayouth JE. Sci Rep. 2021 Jun 23;11(1):13156. doi: 10.1038/s41598-021-92609-x. PMID: 34162987

June 19

• A "Failed" Assay Development for the Discovery of Rescuing Small Molecules from the Radiation Damage.  Wen KK, Roy S, Grumbach IM, Wu M. SLAS Discov. 2021 Jun 19:24725552211020678. doi: 10.1177/24725552211020678. Online ahead of print. PMID: 34151632
• Automated Segmentation of Choroidal Layers from 3-Dimensional Macular Optical Coherence Tomography Scans.  Lee K, Warren AK, Abràmoff MD, Wahle A, Whitmore SS, Han IC, Fingert JH, Scheetz TE, Mullins RF, Sonka M, Sohn EH. J Neurosci Methods. 2021 Jun 19:109267. doi: 10.1016/j.jneumeth.2021.109267. Online ahead of print. PMID: 34157370

June 18

• Characterization of performance and disinfection resilience of nonwoven filter materials for use in 3D-printed N95 respirators.  O'Shaughnessy PT, Strzelecki B, Ortiz-Hernandez M, Aubin P, Jing X, Chang Q, Xiang J, Thorne PS, Stapleton JT. J Occup Environ Hyg. 2021 Jun;18(6):265-275. doi: 10.1080/15459624.2021.1913283. Epub 2021 May 14. PMID: 33989113
• Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche.  Sarnowski C, Cousminer DL, Franceschini N, Raffield LM, Jia G, Fernández-Rhodes L, Grant SFA, Hakonarson H, Lange LA, Long J, Sofer T, Tao R, Wallace RB, Wong Q, Zirpoli G, Boerwinkle E, Bradfield JP, Correa A, Kooperberg CL, North KE, Palmer JR, Zemel BS, Zheng W, Murabito JM, Lunetta KL. Hum Reprod. 2021 Jun 18;36(7):1999-2010. doi: 10.1093/humrep/deab086. PMID: 34021356
• Prolonged Reactive Oxygen Species Production following Septic Insult.  Jensen IJ, McGonagill PW, Berton RR, Wagner BA, Silva EE, Buettner GR, Griffith TS, Badovinac VP. Immunohorizons. 2021 Jun 18;5(6):477-488. doi:10.4049/immunohorizons.2100027. PMID: 34145054
• TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling.  Arkee T, Hostager BS, Houtman JCD, Bishop GA. J Immunol. 2021 Jun 18:ji2001220. doi: 10.4049/jimmunol.2001220. Online ahead of print. PMID: 34145060

June 16

• Radiomics side experiments and DAFIT approach in identifying pulmonary hypertension using Cardiac MRI derived radiomics based machine learning models.  Priya S, Aggarwal T, Ward C, Bathla G, Jacob M, Gerke A, Hoffman EA, Nagpal P. Sci Rep. 2021 Jun 16;11(1):12686. doi: 10.1038/s41598-021-92155-6. PMID: 34135418 Free PMC article.
• Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity.  Chu H, Shuai H, Hou Y, Zhang X, Wen L, Huang X, Hu B, Yang D, Wang Y, Yoon C, Wong BH, Li C, Zhao X, Poon VK, Cai JP, Wong KK, Yeung ML, Zhou J, Au-Yeung RK, Yuan S, Jin DY, Kok KH, Perlman S, Chan JF, Yuen KY. Sci Adv. 2021 Jun 16;7(25):eabf8577. doi: 10.1126/sciadv.abf8577. Print 2021 Jun. PMID: 34134991

June 15

• Middle East respiratory syndrome coronavirus Spike protein variants exhibit geographic differences in virulence. Wong LR, Zheng J, Sariol A, Lowery S, Meyerholz DK, Gallagher T, Perlman S. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2102983118. doi: 10.1073/pnas.2102983118. PMID: 34099556 

June 10

• Activation of the Central Renin-Angiotensin System Causes Local Cerebrovascular Dysfunction.  De Silva TM, Modrick ML, Grobe JL, Faraci FM. Stroke. 2021 Jun 10:STROKEAHA121034984. doi: 10.1161/STROKEAHA.121.034984. Online ahead of print. PMID: 34107734

June 8

• SARS-CoV-2 takes its Toll.  Sariol A, Perlman S. Nat Immunol. 2021 Jun 8. doi: 10.1038/s41590-021-00962-w. Online ahead of print. PMID: 34103714.

June 7

• Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts.  Akintoye E, Afonso L, Bengaluru Jayanna M, Bao W, Briasoulis A, Robinson J. J Am Heart Assoc. 2021 Jun 7:e019589. doi: 10.1161/JAHA.120.019589. Online ahead of print. PMID: 34092110 

June 4

• Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5. Sobreira DR, Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, Claussnitzer M, Aneas I, Nóbrega MA. Science. 2021 Jun 4;372(6546):1085-1091. doi: 10.1126/science.abf1008. PMID: 34083488.
• Ketogenic Diet with Concurrent Chemoradiation in Head and Neck Squamous Cell Carcinoma: Preclinical and Phase 1 Trial Results.  Ma DC, Anderson CM, Rodman SN, Buranasudja V, McCormick ML, Davis A, Loth E, Bodeker KL, Ahmann L, Parkhurst JR, Sun W, Follmer KR, Simons AL, Buatt JM, Spitz DR, Fath MA, Allen BG. Radiat Res. 2021 Jun 4. doi: 10.1667/RADE-20-00150.1. Online ahead of print. PMID: 34087943.

June 3

• Axonopathy precedes cell death in ocular damage mediated by blast exposure. Boehme NA, Hedberg-Buenz A, Tatro N, Bielecki M, Castonguay WC, Scheetz TE, Anderson MG, Dutca LM. Sci Rep. 2021 Jun 3;11(1):11774. doi: 10.1038/s41598-021-90412-2. PMID: 34083587.

June 2

• Hypervigilance, Allostatic Load, and Migraine Prevention: Antibodies to CGRP or Receptor. Blumenfeld A, Durham PL, Feoktistov A, Hay DL, Russo AF, Turner I. Neurol Ther. 2021 Jun 2. doi: 10.1007/s40120-021-00250-7. Online ahead of print.PMID: 34076848.

June 1

• Coronavirus-specific antibody production in middle-aged mice requires phospholipase A2G2D.  Zheng J, Meyerholz D, Wong LR, Gelb M, Murakami M, Perlman S. J Clin Invest. 2021 Jun 1;131(11):147201. doi: 10.1172/JCI147201. PMID: 34060490.
• In reply-COVID-19: Precision Medicine and Vascular Endothelium. Cresci S, Ahmad F, Pereira NL. Mayo Clin Proc. 2021 Jun;96(6):1672. doi: 10.1016/j.mayocp.2021.04.006. Epub 2021 Apr 19. PMID: 34088425 Free PMC article.
• The potential role of MR-guided adaptive radiotherapy in pediatric oncology: Results from a SIOPE-COG survey.  Seravalli E, Kroon PS, Buatti JM, Hall MD, Mandeville HC, Marcus KJ, Onal C, Ozyar E, Paulino AC, Paulsen F, Saunders D, Tsang DS, Wolden SL, Janssens GO. Clin Transl Radiat Oncol. 2021 Jun 4;29:71-78. doi: 10.1016/j.ctro.2021.05.008. eCollection 2021 Jul. PMID: 34159265 Free PMC article.
• The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent.  Harper MM, Boehme N, Dutca LM, Anderson MG.Invest Ophthalmol Vis Sci. 2021 Jun 1;62(7):13. doi: 10.1167/iovs.62.7.13. PMID: 34106210.
• Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy.  Petronek MS, Stolwijk JM, Murray SD, Steinbach EJ, Zakharia Y, Buettner GR, Spitz DR, Allen BG. Redox Biol. 2021 Jun;42:101864.doi: 10.1016/j.redox.2021.101864. Epub 2021 Jan 16. PMID: 33485837 Free PMC article. Review.